Alcohol and Insulin Resistance with Dr. Ben Bikman

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Published 2024-06-20
In this episode of The Metabolic Classroom Dr. Ben Bikman focused on the effects of alcohol on insulin resistance, emphasizing how ethanol, the main form of alcohol, influences the brain and metabolism. He highlighted that alcohol is primarily metabolized by the liver and can cause insulin resistance through both direct and indirect mechanisms. Dr. Bikman detailed the molecular pathways by which ethanol inhibits insulin signaling, notably by disrupting the insulin receptor substrate (IRS1) and increasing oxidative stress, which impairs insulin's ability to regulate glucose.

Ben provided evidence from studies demonstrating ethanol's impact on insulin resistance at the cellular and whole-body levels. Research showed that ethanol consumption leads to higher insulin responses during glucose tolerance tests, indicating a reduced sensitivity to insulin. This phenomenon was observed in healthy humans who experienced a significant increase in insulin levels after consuming alcohol, suggesting a profound metabolic shift due to ethanol's presence.

The lecture also covered indirect effects of alcohol on insulin resistance. Many alcoholic beverages contain high amounts of sugar, exacerbating insulin and glucose responses. Alcohol disrupts sleep quality, leading to poor metabolic outcomes and increased cortisol levels, which further contribute to insulin resistance. Additionally, ethanol competes with other metabolic substrates, leading to fat accumulation in the liver and elevated glucose and fat levels in the body.

Dr. Bikman concluded by discussing the inflammatory response triggered by alcohol, particularly through the concept of a "leaky gut," where ethanol causes gaps in intestinal cells, allowing harmful substances like lipopolysaccharides (LPS) to enter the bloodstream and induce inflammation. This inflammation promotes ceramide production, further contributing to insulin resistance. Overall, Dr. Bikman emphasized the significant role of alcohol in metabolic health issues and encouraged mindfulness regarding alcohol consumption to mitigate these risks.

01:10 - Alcohol and Metabolism
02:18 - Direct Effects of Ethanol
03:26 - Insulin Receptor Disruption
06:38 - Whole-Body Impact
08:37 - Ceramides and Insulin Resistance
11:34 - Indirect Effects: Sugar
13:31 - Indirect Effects: Sleep
18:37 - Indirect Effects: Substrate Competition
23:34 - Inflammation and Leaky Gut

Studies Referenced:

(Seiler et al., 2000):
onlinelibrary.wiley.com/doi/10.1111/j.1530-0277.20…

(Shelmet et al., 1988):
www.jci.org/articles/view/113428

(Onishi et al., 2003):
www.sciencedirect.com/science/article/abs/pii/S000…

(Negoro et al., 2005):
www.semanticscholar.org/paper/[Effects-of-ethanol-ingestion-on-glucose-tolerance-Negoro-Marumo/960b19f2dcdb729fcae7d1a58406209740e25c4f

(Metz et al., 1969):
diabetesjournals.org/diabetes/article/18/8/517/353…

(Liangpunsakul et al., 2012):
pubmed.ncbi.nlm.nih.gov/22194417/

Thakkar et al., 2015:
www.sciencedirect.com/science/article/abs/pii/S074…

He et al., 2019:
www.sciencedirect.com/science/article/abs/pii/S235…

#MetabolicHealth #InsulinResistance #AlcoholEffects #BenBikman #Metabolism #HealthEducation #EthanolImpact #CellBiology #MetabolicClassroom #GlucoseTolerance #HealthyLiving #SleepQuality #DietAndHealth #NutritionScience #Inflammation #LiverHealth #HealthAwareness #MetabolicDisorders #SugarImpact #fitnessandhealth

www.insuliniq.com/

All Comments (21)
  • @nwobob
    One study that has fascinated me is where a rodent group was fed pure ethanol diet, they did not even get fatty liver. When a bit of linoleic acid acid was added to that diet the mice rapidly developed fatty liver, cirrhosis and death.
  • @nwobob
    Not mentioned today is the well documented data that alcohol users even heavy regular use, have lower blood sugar and HbA1c. I expect this is because alcohol inhibits glujconeogeneis at the level of the liver. I have done many experiments with CGMs to prove to myself without any question that blood sugar drops quite precipitously after alcohol ingestion. This is well known in the Medical field where bad alcoholics can have life threatening hypoglycaemia. In my case where I am fat adapted my blood sugar can drop to what would be considered normally as life threatening levels (below detection on the CGM) yet I am completely asymptomatic. I assume because my brain is used to ketone metabolism. This is not to encourage ethanol ingestion, just some interesting side notes. I choose to drink very rarely in moderation.
  • I believe everything you say so i must be a weirdo.i am female and have had hardcore insomnia for 40 years.i have run marathons with no sleep.hiked big peaks with no sleep and no food.i don't get tired during the day,never take a nap.easy to fall asleep,never stay asleep.the most i sleep i get at one time is 3.5 hours.yes, have had sleep studies.no one can help with the insomnia.i have been offered sleeping pills.i don't take them.i don't have sleep apnea.whether i have some wine or not the nights are the same.i have followed advice from everyone who offers it.i have always exercised..in the seventies i was deemed a health nut.even though you can't help me i believe in you and watch every lecture you make. i have learned so much from you.
  • @robinq5511
    Well you have convinced me that even though I have reduced my alcohol consumption considerably since going Keto, even the occasional wine Spritzer is probably not a good idea when it comes to recovering from my insulin resistance. And my own experience when I disregard this advice has proven it to me. It is good to know why however - Thank you!
  • A lecture on time line and stages from Alcohol cessation to recovery of IR, ROS, A1C, and healing of the endothelial layer would be watched by many. 👍 TY!
  • Thanks Extremely useful data. Clear and very easy to understand. Now i have a better insight of this topic.
  • @Philusteen
    I'll raise a glass to this one! (I mean, it's just electrolytes and water, but still ....🍺🤓)
  • @jamesalles139
    Whoa. Thank you so much, Dr. Bikman for the deep dive. I will be sharing this video with family members
  • Thanks, Ben, for another important teaching. Always helpful, always clear. God bless!😊
  • Once again, you are spot on with content, presentation, and that adorable face. Thank you Dr. Bikman.