Long Covid Associated with Elevated Interferon Levels
Published 2024-02-23
(This video was recorded on February 23rd, 2024)
Roger Seheult, MD is the co-founder and lead professor at www.medcram.com/
He is Board Certified in Internal Medicine, Pulmonary Disease, Critical Care, and Sleep Medicine and an Associate Professor at the University of California, Riverside School of Medicine.
LINKS / REFERENCES:
Spontaneous, persistent, T cell–dependent IFN-γ release in patients who progress to Long Covid (Science Advances) | www.science.org/doi/10.1126/sciadv.adi9379
Viruses and interferon: a fight for supremacy (Nature) | www.nature.com/articles/nri888
Interferon Responses Could Explain Susceptibility to Severe COVID-19 (Medium) | medium.com/swlh/interferon-responses-could-explain…
Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients (Science) | www.science.org/doi/10.1126/science.abc6027
Examination of autoantibodies to type I interferon in patients suffering from long COVID (Journal of medical virology) | pubmed.ncbi.nlm.nih.gov/37698062/
SARS-CoV-2 Mac1 is required for IFN antagonism and efficient virus replication in cell culture and in mice (PNAS) | www.pnas.org/doi/10.1073/pnas.2302083120
Early Treatment with Pegylated Interferon Lambda for Covid-19 (NEJM) | www.nejm.org/doi/full/10.1056/NEJMoa2209760
Hyperthermia in humans enhances interferon-gamma synthesis and alters the peripheral lymphocyte population (Journal of interferon research) | pubmed.ncbi.nlm.nih.gov/3132509/
The biological activity of interferons in post-COVID syndrome (ERJ) | openres.ersjournals.com/content/8/suppl_8/240
Prevalence of persistent SARS-CoV-2 in a large community surveillance study (Nature) | www.nature.com/articles/s41586-024-07029-4#Sec2
Interferon Response in Hepatitis C Virus-Infected Hepatocytes: Issues to Consider in the Era of Direct-Acting Antivirals (International journal of molecular sciences) | www.ncbi.nlm.nih.gov/pmc/articles/PMC7177520/
Treatment of hepatitis C virus infection with interferon and small molecule direct antivirals: viral kinetics and modeling (Critical reviews in immunology) | www.ncbi.nlm.nih.gov/pmc/articles/PMC2882097/
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#covid19 #interferon #coronavirus
All Comments (21)
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For more medical education videos for physicians, nurses, physician assistants, respiratory therapists, EMTs, or anyone else that is curious: Visit us at medcram.com/ We offer CME and CEs. Chronic hepatitis C also is associated with elevated interferon. Despite this, Interferon was used with Ribavirin for years to cure forms of chronic hepatitis C.
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My husband contracted covid in April 2021, was put on a ventilator for 6 weeks, and discharged home from hospital 3 and a half months later. Although he is much better, he still experiences chronic fatigue, tinnutis, and GI symptoms. As a registered nurse, I appreciate well presented videos such as this one that may shed a light on treatment for long covid.
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I asked my Long Covid Doctor at the University Of Iowa about getting tested for this and she said U of I does not offer it. I told her I would send this video to her so she can watch this.
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I had Hepatitis C in the mid 1980's as a 24 year old, after a blood transfusion and was part of the groundbreaking double blind study using injectible Interferon to test its efficacy as a treatment. I received the largest amount of Interferon for 11 months. I now have undetectible amounts of Hepatitis C in my blood as a 63 year old!
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Thank you. I'm a longtime chronic illness patient with multiple autoimmune disease diagnosed, including a rare neurological relapse/remit. I appreciate these updates bc they help keep me safe & connected with my physician + specialists, & Long C symptoms echo my own so I've no doubt I'll be benefitting from things learned from this pandemic. Thank you for helping me learn. I'm looking forward to updates on the next generation of flu + C shots, the ones they are working to release in the autumn with the advent of the flu season in the Northern Hemisphere.
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Absolutely fascinating! Thanks for your great work, it’s people like you who restore my faith in humanity.
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Why are us 20 years having such trouble with this though. Does this mean we are immune compromised or something?
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A similar thing is being studied by Ron Davis and Rob Phair re me/cfs and persistent INF elevation.
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Very interesting. I'm not a health worker but I love all your videos. You have a true passion for scientific discovery. Thank you for sharing your knowledge and your reasoning.
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Hey Dr. , so what can us long covid people do to help ourselves ? Do you do consultations?
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Thank you so much for making this video! Really clear explanation
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Thank you so much.
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Eat garlic, folks. Look up how garlic affects interferon in the body. The old-timers were right, they just did not know the scientific reasons why. If I have a stubborn cold, I make garlic tea, hold my nose, and drink it down. Positive results are almost immediate.
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I'm in Healthcare IT and watch your videos to learn. Thank you.
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Saw that paper today. Looking forward to hearing your breakdown.
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I'm far more interested in learning about the similarities to long covid and adverse reactions to vaccines?
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When I got Covid I worked while I was sick as a solo lawn care owner to the point I coudnt and I didn’t do well I fainted I got dehydrated low oxygen. I haven’t been the same since. I’ve had lung X-ray and they said I looked fine. I still have a caugh years later I worked 38hrs this week and I’m Exhausted I use to do 50hr a week lawn maintenance and wouldn’t be tired. My cat that wouldn’t stay away from me when I was sick not long after got heart disease and had to put him to sleep cause his Lu gs filled with fluid. I think Covid had something to do with it. Covid did something to me and I haven’t been the same ever since. I’ve been dropping lawn accounts so I don’t have to work as much cause I’m always tired.
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Thank you for creating these informative videos that have been a source of valuable information all the way through the pandemic.
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Lets hope that our Gain of Function experts make a new and better virus and save the planet.
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Thank you so much for this data-driven information. Getting more sunlight (due to watching your videos) has genuinely improved my chronic (2 years) LC symptoms. Im going to start hitting a sauna just to see if that can help too. Best wishes.
