Can over the counter Antihistamines help treat LONG-COVID symptoms?

Published 2022-03-14
Lindsay Dixon BSP RPh discusses a study explaining how over the counter antihistamines may be helpful in the treatment of long-COVID, otherwise known as PASC, a condition that has left millions of people worldwide with long lasting symptoms. With no current treatment protocols patients are left searching for answer often from social media support groups and anecdotal evidence they find online.

It is estimated that up to 30% of people who have had COVID-19 infection will take 3 months or longer to fully recover. Many have lingering symptoms for 6-12 months, and many simply do not recover. The symptoms are many: Fatigue, rashes, bruising, difficulty sleeping, memory loss, confusion, muscle and joint pain, and the list goes on.

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Long-COVID (Postacute Sequelae of SARS-CoV-2 - PASC) is having a huge impact on the work force in places like the UK where at least 1 million people report having difficulty going back to work - this is definitely happening in Canada as well. 

There is currently no treatment protocol for PASC and patients are left looking for answers on social media groups and through word of mouth in many cases.

In addition, patients who had COVID-19 early on in 2020, may not have had access to testing and may not know why they are suffering from this post-viral illness. It has been reported that some physicians have often downplayed the symptoms of those with PASC, similar to the experience of patients with Chronic Fatigue Syndrome (Myalgic Encephalomyelitis) or Fibromyalgia.

I have heard anecdotal reports from some people who say that taking antihistamines has helped their symptoms. PASC presents in so many different ways for different people, it was eye-opening to see how in these case reports, published by the Journal of Nurse Practitioners, the addition of an anti-histamine addressed multiple symptoms almost immediately.

Though we cannot conclude precisely how antihistamines could be having this type of effect, it is quite clear that inflammation and an overactive immune system could be part of the culprit behind some of these symptoms. Could antihistamines, by blocking the H1 receptor and therefore blocking the release of histamine in the body be a way to "tone down" this immune response? Possibly.

Though far from being conclusive on whether antihistamines will be an effective treatment for PASC, these over the counter therapies are medications that have a fairly low incidence of side effects (especially 2nd generation antihistamines - I discuss this in the video), they are not very expensive, and do not interact with very many other medications.

You should always consult with your pharmacist or primary care provider before starting any new medication or supplement, as antihistamines are not for everyone, and can have serious implications if taken without the guidance of a healthcare professional.

In any event, these case reports are encouraging and with the incredible amount of research going on worldwide to discover the aetiology and pathophysiology of Long-COVID, those who suffer can be encouraged that the world is eagerly seeking a way to help patients recover from this debilitating condition and each day we get another step closer to helping these patients get back to a better normal.


00:00 How many people have Long-COVID worldwide?
01:17 Case studies from the Journal for Nurse Practitioners on PASC
02:08 What kinds of Antihistamines cause drowsiness
03:13 Facebook support group for LONG-COVID
03:49 Case Study #1
07:22 Case Study #2
08:38 Acrocyanosis with LONG-COVID
09:31 Previous evidence for Antihistamines in COVID-19 Infection
10:22 Evidence of SARS-CoV-2 in multiple body tissues as a reason for widespread symptoms of LONG-COVID
10:59 Call for patient who are suffering to access care for Long-COVID for supportive care

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References:

Antihistamines for Postacute Sequelae of SARS-CoV-2 Infection: www.npjournal.org/article/S1555-4155(21)00547-X/fu…

Quarter of UK employers cite long COVID as driving absences - survey: www.reuters.com/world/the-great-reboot/quarter-uk-…

#COVID-19 #LongCovid #Antihistamines #COVID19treatments #PASC

All Comments (21)
  • Must watch interview coming soon with Radiologist and COVID-19 researcher from the UK Dr. Graham Lloyd-Jones. You will enjoy learning his insights on how COVID-19 affects body systems and how Long-COVID may be occurring. This interview will be available sometime in January 2023. 📍Subscribe with notifications to be alerted of when this interview is posted.
  • @randyb620
    Please read if you have long Covid. This worked for me! I’m not a doctor. I’m male, mid 50’s, average height, slender build. Got jab mar 2021 (required for job) a month or so started having slight difficulty breathing and got slowly worse as time went on. By September 2021 at times would throw up. Thought I was allergic to new dogs. Tried every allergy pill, nothing worked. Then tried Primatene Mist, everything cleared up, no issues with breathing at all. Never had asthma my entire life and now 18 months later still use it when breathing issues arise. Got Covid Jan 2022. Few weeks later slowly started having heart issues, skipping heart beats, instant high BPM, massive pounding heart beats. Did battery of tests at cardiology dept, they found no issues at all, along with other docs saying there is nothing medically wrong. The worst for me was feeling like is was going to faint multiple times a day. Mainly standing outside and talking, driving to work at night after dinner, and while at work sitting. Fainted once at work. Had to go on medical leave for months. Started to get better then it all came back slowly (also anxiety with almost panic attacks). Watched so many long covid videos and read 1,000+ comments and took notes on what people did. This is what i did and worked (i’d say I’m 95% free at this point). I stopped taking powder fiber supplements (can cause iron not to be absorbed). I’ve only eaten lunch and dinner before but now had carnation instant breakfast with milk in the AM and a banana with a men’s 50+ multi vitamin and one iron supplement pill at that time. Normal lunch and dinner but tried to have a more protein involved. Snacked on pumpkin seeds, sunflower seeds and beef jerky. An apple around 3pm. Would mix a packet of propel electrolytes with a few shakes of table salts in it and drink throughout the day. At dinner would take another multi vitamin and another iron pill. At night before bed took an Antihistamine pill. Would try and eat smaller meals more often throughout the day and night. Worked out on elliptical 25 minutes every other day. At 3 days noticed a feeling of not so severe symptoms. Every day was better and better and 3 weeks later, 0 skipping heartbeats, no feeling of fainting, no pounding heart. An amazing feeling just to feel normal after a year and a half of issues everyday. Hope my story and remedy works for at least one person
  • @JK-kk9bb
    You are an amazingly wonderful person for using the correct term of Myalgic Encephalomyelitis, and completely leaving out the insulting slangs that are often used. On behalf of the millions of people whose lives are destroyed by M.E., I want to say thank you from the bottom of my heart. If all medical professionals were as considerate and professional as you are, our lives would be better. Thanks again!
  • Finally a TRUE professional. You are a breath of fresh air in a world of medical garbage. You have clearly demonstrated the difference between a true professional and someone who possesses a medical degree and I admire you for having the courage and integrity to shine a light on the unacceptable behavior of the mainstream medical industry. What a joke they are intentionally dismissing what is right in front of them. Mainstream medical does the complete opposite of the do no harm oath. Thank you so much for taking the time to create and present this video.
  • @reallauradee
    Talking with a doctor sometimes becomes a wall where no answers or no directions are given, especially from those doctors who get annoyed because they think they know better than the patient who's coming to them with questions about something they read or seen online. That's why I've always went ahead with self-medicating after months of research; I was able to stabilize my Bipolar II with a supplement to the point where I no longer needed prescription medication. As for my long COVID symptoms, I will talk to my family doctor, but knowing him, I'm just going to get that common chuckle and small eye roll and hear "there's no treatment." Then I'll head to my local CVS and find some antihistamines.
  • @kristen1441
    They’ve helped me! I’m a viral immunologist that has worked on vaccines. I do hydroxizine at night and lorantidine in the am. Within a week I had far more energy! Check with your doctor before beginning any treatment!
  • @joelee5875
    I have been so sick for so long...over 9 months now and after all the doctors I've seen one definitely gets the feeling that all of the doctors wish that things could go back to the good old days when they could say that they knew at least a thing or two...to date, they do not understand anything about the post covid problems, I won't go into the 3 MRIs the CAT scan the 10 blood draws, etc. etc. But...I will give anyone going through this some hope as I do understand that this is a persistent and ugly sickness. I will tell you to get lots of rest and don't panic about being stuck inside (I did panic for a while) but I also found that slowing down my body through meditation actually helps...and I know that some people don't meditate...I was feeling desperate when I first tried this and was amazed at how much better I felt... (I do these in 20-minute intervals now) and at the end of 20 minutes, I actually felt the symptoms disappear the first time that I tried this, it was like waking up and this I believe has helped push my body into straightening itself out, although in a mild way... but it gives the body a push into the right direrction telling it to relax and heal itself. I'm not sure about these over-the-counter drugs but they gave one of my sisters Mucinex while she was in the hospital for a covid attack so after writing to you all about some of the solutions I've found, I'm going to take a couple myself and see if they help at all. My intent in writing this is only to be of service to anyone who is feeling the effects of long covid- hang in there. Don't lose hope, It will get better- Best of luck to all of you.
  • @holmes592
    I got Covid virus is sept 2020. My biggest complaints are shortness of breath during aerobic exercise (heart palpitations) . I also have brain dysfunction of organizing simple task such as generalization of banking or financial discrepancies. Reading simple financial contracts is a nightmare for me. That has always been a very strong attribute in my line of business. Doctors do not listen to me because I am now 63 years old and they contribute it to my age. I am so angry and feel helpless.
  • Thank you for bringing up this very relevant research . It helps a lot adding to not dismiss a pts unusual symptoms .
  • @AddamSolo
    You truly do have a gift for analytics, research, presentation and speaking.
  • @9jmorrison
    Stinging nettle helps block food reactions.
  • @sonrog8877
    Really appreciate the helpful & concise information
  • @schembfs
    Mystery Solved! I'm a middle aged M in a 4 person household. I'm not particularly healthy, with prediabetes, high cholesterol, gout and i do not exercise. However i have never smoked, done drugs and only occasinally drank alcohol. My entire household (all fully vaccinated) stopped taking covid precautions (masks and constant hand washing) early this year (2023) and sure enough got Covid for the first time...except me. My wife (a nurse) kept testing me to see if i was just asymptomatic, but i never tested positive. This video made me realize possibly why. I have been taking benadryl (25mg) every night to deal with insomnia for the last several years. Being aware of my not particularly healthy diet (lots of red meat), i also have started daily low dose aspirin about 4 years ago. However, since my prediabetes diagnosis 2 years ago, i have completely stopped my previously high intake of sugary drinks (cocacola classic).
  • @josephtpg2205
    I am a long hauler. I have found that night histamine levels are the most important. Short duration Also night gut health. Sunlight also
  • @freecanuck
    Thank you so much. Have had lingering symptoms for months. Was a healthy, active 56 yr old male. Going to Pharmacy tomorrow for antihistamines.. Will do some ingredient research. Your video has the potential to help alot of frustrated, fed up people. Feel fortunate I stumbled across one of your videos last week, and Subscribed. You are a Blessing. Again, Thank you soooooo much. Be well Smart Lady.
  • @marcd1981
    Thank you for the video. This is March 31, 2024, and I believe I could be suffering long Covid symptoms after getting Covid for the second time one year ago (March of 2023). EDITED RESPONSE: I'm adding this information as an edit: I am 61, 5' 9", 160lbs, and my wife and I have been very fit out entire adult lives. We strength train 3 days a week, are in a stair climbing group every Saturday morning, we eat well, and I am not a drinker of alcohol. I was in what i considered the best shape I had been in over the past 15 years when this started last July (2023). Now, I try to get as much exercise as I can, but nowhere near what we were doing last year. If there is any type of pain, I stop. And then afterwards there is usually a lot of tightness in my right flank, like a severe cramping. I also believe I am at the stage mentioned in this video where the doctors are not believing anything is wrong with me, because of all of the imaging (CT scans, Ultrasounds, and MRI's) not showing anything was "wrong", and all of my blood panels being normal. It has been 9 months since my symptoms were severe enough to have my wife drive me to the ER with severe low back pain on the right side. That was the first CT scan, looking for kidney stones, of which there were none, with all organs showing as normal. Fast forward 9 months and 12 doctors later, I have pain in my right flank / abdomen from when I wake up until I go to bed. All day, every day pain for 9 months. None of the doctors (Providence, Cedars-Sinai and Keck of USC) can tell me what this is. They can tell me what it isn't, but that has not been much help. I do have some of the other symptoms, brain fog, headaches, insomnia over the past 2 months, that nothing over the counter I have tried has worked. My wife just showed me this video, as we are about to do our food shopping this afternoon, and wanted to see if trying an antihistamine is something I would do. As stated in this video, they have been around, are inexpensive, and relatively safe to try. So, I will try this and come back to this video in a week to see if there is an improvement.