Debunking Sugar Claims: What Dr. Lustig Got Wrong On The Huberman Podcast

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Published 2024-01-25
This week, Paul talks to Mike Fave, critical care RN about all things sugar & fructose. They share their thoughts on a recent podcast with Andrew Huberman and Alex Lustig, and why they disagree with certain points made about insulin, fruit juice, and fructose.

*Produced by ⁠Mountain Valley Media

00:00:00 Podcast begins
00:04:00 Mike’s background
00:05:15 Diving into fructose
00:13:00 Thoughts on honey and other carb sources
00:27:30 Robert Lustig rebuttal: is fructose addictive?
00:37:40 Fructose & fiber
00:47:00 How fructose affects the mitochondria
00:51:00 Clarifying hyperglycemia vs. a postprandial hyperglycemia
00:56:17 Is insulin the bad guy?
01:12:20 How insulin relates to diabetes, obesity, and insulin resistance
01:23:30 Balancing protein, fat and carbohydrates
01:30:00 Is fructose making us fat?
01:46:00 Final thoughts


Connect with Mike:
Mikefave.com
youtube.com/@MikeFaveSimplified


References:
Review article: fructose malabsorption and the bigger picture: onlinelibrary.wiley.com/doi/10.1111/j.1365-2036.20…

A Relationship between Reduced Nucleus Accumbens Shell and Enhanced Lateral Hypothalamic Orexin Neuronal Activation in Long-Term Fructose Bingeing Behavior: www.ncbi.nlm.nih.gov/pmc/articles/PMC3988143/

A High-Fat Meal, or Intraperitoneal Administration of a Fat Emulsion, Increases Extracellular Dopamine in the Nucleus Accumbens: www.ncbi.nlm.nih.gov/pmc/articles/PMC4061790/

A Relationship between Reduced Nucleus Accumbens Shell and Enhanced Lateral Hypothalamic Orexin Neuronal Activation in Long-Term Fructose Bingeing Behavior: www.ncbi.nlm.nih.gov/pmc/articles/PMC3988143/

The regulation of glucose metabolism: implications and considerations for the assessment of glucose homeostasis in rodents: journals.physiology.org/doi/full/10.1152/ajpendo.0…

Consumption of Raw Orange, 100% Fresh Orange Juice, and Nectar- Sweetened Orange Juice—Effects on Blood Glucose and Insulin Levels on Healthy Subjects: www.ncbi.nlm.nih.gov/pmc/articles/PMC6770506/

The Effects of Soluble Dietary Fibers on Glycemic Response: An Overview and Futures Perspectives: www.ncbi.nlm.nih.gov/pmc/articles/PMC9736284/#B37-…

The Effects of Soluble Dietary Fibers on Glycemic Response: An Overview and Futures Perspectives: www.ncbi.nlm.nih.gov/pmc/articles/PMC9736284/#B37-…

Formation of Fructose-Mediated Advanced Glycation End Products and Their Roles in Metabolic and Inflammatory Diseases: www.ncbi.nlm.nih.gov/pmc/articles/PMC5227984/

Altered glycolytic and oxidative capacities of skeletal muscle contribute to insulin resistance in NIDDM: pubmed.ncbi.nlm.nih.gov/9216960/

Glucagon and type 2 diabetes: the return of the alpha cell: pubmed.ncbi.nlm.nih.gov/25344790/

Insulin, growth hormone and sport: pubmed.ncbi.nlm.nih.gov/11431133/

Effect of Mild Physiologic Hyperglycemia on Insulin Secretion, Insulin Clearance, and Insulin Sensitivity in Healthy Glucose-Tolerant Subjects: www.ncbi.nlm.nih.gov/pmc/articles/PMC7881846/

Fructose metabolism in humans – what isotopic tracer studies tell us: www.ncbi.nlm.nih.gov/pmc/articles/PMC3533803/

Absorption capacity of fructose in healthy adults. Comparison with sucrose and its constituent monosaccharides: www.ncbi.nlm.nih.gov/pmc/articles/PMC1433856/

Review article: fructose malabsorption and the bigger picture: onlinelibrary.wiley.com/doi/10.1111/j.1365-2036.20…

Toll-like receptor 4 is involved in the development of fructose-induced hepatic steatosis in mice: pubmed.ncbi.nlm.nih.gov/19637282/

Fructose Promotes Leaky Gut, Endotoxemia and Liver Fibrosis through CYP2E1-Mediated Oxidative and Nitrative Stress: www.ncbi.nlm.nih.gov/pmc/articles/PMC6783321/

All Comments (21)
  • @MikeFave
    It was great riffing on Fructose together Paul! Thanks for having me on, looking forward to collaborating again in the future 👍
  • I love all the nuances you provide in your discussions. Thanks for sharing with us.
  • @slimbrady6004
    I always appreciate when experts invite other people on their platform because they disagree. It results in a great conversation, and I always walk away with new knowledges
  • @cccmmm13
    Wish you got to interview Dr. Peat RIP
  • DR Paul ,last year i lost 70lbs using keto+IF from February to august. I transitioned over to animal based in September and i have not gained any additional weight. In fact i starting hitting the gym 1 or 2 times a week and ive put on some muscle mass very quickly. I still fast atleast 18hr a day while being animal based . I add fruit in almost every day, i eat a table spoon of honey before bed nearly every night and i sleep like a baby. I eat alot of fermented foods like raw cheese, pickles, yogurt, sourdough bread , cottage cheese and ive never felt better ! Thank you for posting
  • @geraldtaylor189
    Thanks paul for the podcast, I am however more confused now that before on what is the proper human diet. I think the only way my confusion will be addressed is to have Dr.Lustig on your podcast and thankyou for inviting him to come on. I will be anxiously anticipating that podcast. Should be epic.
  • Hi Dr. Paul... I love your videos. I have a huge admiration crush on you! I started out in nursing many years ago and continued to study the body and how it works even after I moved away from nursing as a profession. I knew when I first heard you that you are correct and that carnivore alone is not the best human diet. I studied for several months before deciding to work away from destructive eating habits to learn how to properly eat for my body. I did elimination at first then began to learn what works for me and what doesn't. Vegetables were the center of my diet. Once I took them away for 30 days I realized how much they were messing up my gut and hormones. My body cued me each month what to take away and what it wanted me to eat. I listened. It has been a year now and although I am still working some things out... for the most part it is simple. I have the energy and vitality I need to do all that I want to do now. Fatigue and poor health stopped me from pursuing my goals and dreams. I am a licensed massage therapist specializing in hot stone therapies by trade, but it is time for me to transition into new things. I needed the energy in both my body and mind to do this. A few months ago I got started publishing my books. I am about to start working on photography for my books as well. In the past I made short films and recorded some songs. I love the arts even though I also have a scientific mind. My degree is in the arts. My teachers always called me an enigma of the scientific mixed with the deep creativity of the arts. This is actually true... I love the arts, but I also love whole health and understanding how the human body works optimally. One topic I have not seen a lot of discussion about is hormones and menopause from a been there done that perspective. It was very obvious that vegetables threw me into early menopause and messed up my hormones so badly that my bones ached most of the time. My gut health was a mess... therefore my immune system was not able to perform as it should. Meat, meat fat, fruit, honey and eggs took me off the bio identical hormone replacement in 3 months. I have not eaten vegetables in a year. It had a huge effect in helping to clear up gut and hormone imbalance. There was no doubt that the vegetables were the catalyst for the disaster that took place in my body. I have more energy now than when I was in my twenties, my hormones are in balance and my mind is clear. I only need to eat two meals a day and a cheese snack before bed. I used to be so hypoglycemic that I had to eat every two hours from the time I got up until bed time. My thyroid was a mess. My body temperature was always off. People really need to be shown the truth. It is huge. If you ever want to talk with me about this I would be happy to give you my input and answer any questions I can for you. You can find my books to date on Amazon by typing my full name into the search bar. Heidi Lynn Borden. I have several books out on the market to date of various kinds. I write, design and construct my books. My son is my illustrator. My creativity has definitely been enhanced by the change in eating and a clear mind. Thank you for all that you are doing Dr. Paul! You are greatly appreciated! Many blessings to you! Heidi Lynn
  • @skunkyboy69
    YOU GOT MIKE ON! CHRISTMAS CAME EARLY THIS YEAR
  • @user-ne6cq6kh8r
    Hey Paul - this is great! Thank you so much for doing this podcast - it's nice to have a fact check on Dr. Lustig. My take here is that he's studying the 90% of the people who are not healthy, but attributing the findings to apply to people in general. Similar to how I just heard on DeLauer's podcast that sugar's bad effects were only present in a situation where there were also trans fats in the diet. Really great stuff, to dig deep enough to get more complete answers on things, Mike. Thanks.
  • @JoylieC
    Wonderful discussion! Thanks to you both. 🎉
  • @fabsadami
    If you read Lustig’s books, he is actually quite specific that it s PROCESSED, refined sugar that is the problem, not sugar inside the food matrix. Processed food is his key message and on that i believe, you agree.
  • @srmitch9260
    So glad to see how Paul has ditched the low carb / Keto / meat only carnivore diet. He managed to peel back the layer and understand that carbohydrates are not inherently problematic. Thanks Paul. Great video.
  • @Joy80JJ
    This interview is one of your best. I have been afraid of sugar & Dr Lustig for years. Learned alot from this.
  • @johnburn872
    Paul you have to get Dr. Lustig on your podcast
  • I'm grateful to have encountered this particular podcast. I've heard this Dr. Llustig since I started Youtubing around 2015. I have always respected him, but I always bothered by his tonality. He always delivers his messaging with generous doses of condescending anger. He delivers it in way that I was never able to buy it all. He presents lots of authoritative claims and uses extreme metaphors to get his snide point across. A brilliant man, I can see, but nobody I know of hates sugar more. (He equates it to Agent Orange or Napalm). Nice to see and hear counterclaims in the most gentlemanly way.
  • @EdV978
    Great interview Mike and Paul
  • @mcut1217
    This podcast was great! I loved every minute of it!
  • @hyperTorless
    Based Mike ! His podcast with Jay Feldman is amazing!