Why Are There So Many Antihistamines? 🤧💊

Check out the description for sources and links to the books I read in preparation for this video!

You can also use em to see spiders and eldritch shadow beings

If cetirazine is non-drowzy then those first generation ones must have been a real knock out.

Hey, pharmacist here. Just wanted to let you know that I LOVE your videos on all the medications so far. I absolutely love the pharmacology segments too. Keep up the amazing work!!

I love how in modern medicine, each step builds off one another.

I still can't believe this channel hasn't really taken off yet. Such good videos!

Not a single mention of the Benadryl Hat Man

great content to watch while staying indoors at the peak of pollen allergy season :)

I'm so thankful for the discovery of diphenhydramine. Im allergic to a plethora of foods. And it has saves my life on multiple occasions, especially when I was 45 minutes or more away from a hospital. Food allergies suck, especially when you develop them later in life. When I was a kid, I didn't have any allergies. I developed all of them as a teenager. Now I can't eat some of my favorite foods. Peanut butter used to be my go-to food when I was hungry but couldn't really figure out what I wanted to eat, but now I can't eat it. And I can't eat almonds either. I can't even pick up walnuts, if I do my hands swell turn red and get extremely itchy. Those were some of my favorite foods as a kid.

It’s funny how cetirizine is marketed as “non-drowsy”, since even 5mg leaves me too tired to move, although I can still think clearly. IIRC about 1 in 10 patients reacts the same way, it’s not few. Loratadine and fexofenadine I’ve had better luck with. A friend of mine tells me fexofenadine is the only one approved by the FAA for pilots, which might be saying something. Also I’m glad to see you’re learning about the hatman today. Memes aside, it’s interesting stuff. Diphenhydramine overdose (whether unintentional or recreational) seems to have a lot in common with sleep paralysis, where it’s hard to tell the difference between what’s really happening and what you’re afraid might happen. (I’ll pass!)

Claritin/loratadine's trip is wild...I remember when it was a dollar a pill...now I can buy a year's supply (365 pills) for under $12 😳

How good is this man at making videos? He makes me consider paying money to see him talk about thorazine

Antihistamines are also anticholinergic, which is linked with an increased risk of dementia with long-term use. There is less risk with some of the newer antihistamines - Claritin, Alavert, Zyrtec.

Thank you for going over the difference between intrinsic effects and affinity - I was trying to explain the difference between methadone and buprenorphine, and why buprenorphine isn't STRONG than methadone, in its effect but is much stronger in it's receptor binding. In fact it's affinity for the opioids receptor is almost unparalleled by any opioid, but it's efficacy is much less than most of them

I've experienced doxylamine as a calmative...unfortunately it was after mistaking paracetamol with doxylamine for normal paracetamol. Before a lecture. I wrote half a page of gibberish then passed out.

I've been on some antihistamines for mental health care. One was originally for allergies, but now commonly used to treat MS, and off label use is common for antidepressant intolerant individuals like myself. It worked for a bit, but found some better answers and solutions. Mostly getting on fibromyalgia meds helped with energy and pain, which improved my mental health. Crazy how some of these meds end up being used for something completely different. Edit: I misremembered. The antihistamine I was on for a while was used for anxiety and panic attack disorders. The off label med for depression was originally an antiviral.

As a kid, spring allergies made it impossible for me to get through a school day. Thankfully, I discovered Benedryl which helped me sleep through most of it.

Brilliant. I had no idea of the amazing history of a drug I rely on every spring. Thank you.

Perfect timing :) Was just chatting with a friend about these the other day!

It’s so funny because I’m a pharm tech and I’m always asking questions…me and my pharmacist were just talking about histamines yesterday