Epstein Barr Virus (EBV) Serology

Published 2021-07-31
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. Epstein Barr Virus (EBV) Serology

Let’s review the serology of the Epstein Barr Virus (EBV). EBV causes Infectious Mononucleosis. This disease is usually benign and self limiting. However, in some cases it can become chronic, or reactivating. EBV can also cause cancers and other serious complications. Let’s review the serology of the EBV.

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About infectious Mononucleosis
www.ncbi.nlm.nih.gov/pmc/articles/PMC4670567/

CDC on EBV Serology
www.cdc.gov/epstein-barr/laboratory-testing.html

Serological diagnosis of Epstein-Barr virus infection: Problems and solutions
www.ncbi.nlm.nih.gov/pmc/articles/PMC3782265/

The Relationship Between Environmental Factors and the Profile of Epstein-Barr Virus Antibodies in the Lytic and Latent Infection Periods in Healthy Populations from Endemic and Non-Endemic Nasopharyngeal Carcinoma Areas in China
www.thelancet.com/article/S2352-3964(18)30073-2/fu…

Epstein-Barr virus (EBV), Infectious Mononucleosis
labpedia.net/epstein-barr-virus-ebv-infectious-mon…


High level overview of the serology
States of a person:
Susceptible to EBV (never had it before.)
No antibodies

Acute infection
VCA IgM

Acute infection late acute
VCA-IgM and increasing VCA-IgG

Past infection
VCA-IgG and EBNA-1 IgG

Reactivation of the EBV
www.ncbi.nlm.nih.gov/pmc/articles/PMC3782265/
High EA (D) IgG
Increasing VCA-IgG
Decreasing EBNA-1 IgG
Even VCA-IgM may reappear during the reactivation

Immunosuppressed may have
Only EBVCA IgG without EBVCA IgM or EBNA-1

In 1.7% of the infected patients may only show EBNA-1 without EBVCA-IgG (this pattern is usually thought to be implausible.)

Antibody patterns and causes from LabPedia
labpedia.net/epstein-barr-virus-ebv-infectious-mon…

#DrBeen #EBV #InfectiousMononucleosis ...

Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional. ...

Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional. ...
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.

All Comments (21)
  • @kevineakins5276
    An excellent series of lectures. Top class. I have never heard ebv pathology & characteristics presented so clearly.
  • @ZlayaCo6aka
    Another thing that might be helpful: According to several medical articles I've read, backup symptoms of a chronic EBV infection are chronic vitamin-D and vitamin-B12 deficiencies. In my case, vit-D is typically between 10 and 25 even though I took 20,000 IU per day of supplements. I now take 40,000 per day and my vit-D is approaching 30. B12 is barely in the green, and homocysteine is significantly elevated. These test results/conditions have been consistent for more than 15 years. Doctors always dismiss these results with: "Everyone is low."
  • @paulette-rose
    Wow! Thank you Dr. Mobeen! You keep my 72 year-old brain active and healthy by all this teaching!!😄 This was wonderful!
  • @manarsmaan2624
    What a great doctor. This video will help me with my ASCP board exam and i am so thankful to you.
  • @ZlayaCo6aka
    Something that might be helpful, that I hope will be addressed in a follow-up lecture: The sample source for EBV-PCR tests MATTERS, whether whole blood or plasma/serum. In my case, every PCR that used whole blood was positive (in the 1000 to 9999 range,) and every PCR that used plasma/serum was negative. There are articles in the medical journals that explain why, and how the loads and ratios of simultaneous PCR tests correlate with EBV-related illnesses. Basically, when whole blood is processed into plasma/serum, infected cells are removed from the sample before testing. Unless the subject has "cell-free DNA" in the plasma/serum, the PCR will be negative. In my case, every doctor upon receiving a negative PCR result immediately dismissed EBV as the cause of my illnesses. But, in my case it gets worse: VCA-IgG is always over 750, EBNA is always negative, and whenever my misery peaks EA is positive (otherwise it's negative.) So far, every doctor diagnosed "recent infection" even though my history with EBV goes back to 2003 when I had severe mono, complete with the classic rash, for more than 9 months. Also, IgM is positive only when I experience a reactivation, which is evidenced by severe viral syndrome with fever over 101 for up to 16 days. My reactivations have always been diagnosed as primary infections because EBNA is always negative, even though youth is a distant memory. The degree of EBV-ignorance in the medical profession is staggering, at the very least. So, I hope the doctor will address these subjects in a future video!
  • Dr. Been is beaming with joy: he has a mechanism to describe:))) And rightfully so-he is so good at that!!! Respect!!!
  • @weloveourkittens
    Thank you so much for clarifying the tests, chronic versus reactivation and the great helper you said at the end to use in reactivated state. I am in reactivated state taking numerous supplements but will add the ivm also.
  • Unfortunately the “doctors” who need to hear this information are most likely the doctors that will not hear this information or even worse not allowed to apply this information to there practice.
  • @ZlayaCo6aka
    I've had several severe reactivations but have NEVER been EBNA positive.
  • @cristinaco7952
    Thank you Dr.Mobeen , learn a lot .God bless you 💖🌹
  • @medico52
    Could share what app /software you use to share your screen and live stream. Excellent for teaching
  • Do you believe during the reactivate phase that fibromyalgia is developing and getting magnified each time?
  • @MV-uh7kr
    Good to know all this info about Mono.
  • @upserrudy
    good morning Dr Been. I had a question about some titers. my IGG levels have always been over >600 or >1200 My wife and everyone I know has levels within normal range. All the docs I have seen say they don't know why my levels stay like this. Can u shed some light on why my IGG levels made so much more than normal levels?
  • This is extremely informative, and I would like to just tickle the idea that Acyclovir may be effective in treating the presence of reactivated EBV in Hashimotos??? Cystic ovaries in a woman diagnosed with polycystic ovarian syndrome??? Could there be a connection??? And are there past studies on this matter???
  • @ItsAV2023
    Great lecture. Thank you so much! I had no idea about the connection between latent EBV and various cancers. Do you have an informational lecture like this on the other herpetic virus strains? I’m looking to study up on CMV and Shingles? Thank you!
  • I can see a link here with chronic relapsing multiple sclerosis and it’s cycles too ~ and how the immune system goes into inflammatory mode at times as these B cells may well attack our own tissue. I too take IVM monthly and find it helpful. You have a wonderful brain and an amazingly big heart Dr Been. Can you use that big brain of yours to look at EBV and MS?