Whipple Disease | Causes, Risk Factors, Pathophysiology, Symptoms, Diagnosis, Treatment

JJ Medicine
JJ Medicine
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Published 2020-08-19
Whipple Disease | Causes, Risk Factors, Pathophysiology, Symptoms, Diagnosis, Treatment

Whipple disease is a very rare systemic infection caused by the gram positive bacteria Tropheryma whipplei. Illness is caused by issues in host immunity, leading to a variety of inflammatory affects in multiple systems of the body. Because of this, the clinical features are varied and can include gastrointestinal, neurological and rheumatological symptoms. Diagnosis is often difficult because of this, and treatment involves chronic use of antibiotics.

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NOTE: Sorry for my pronunciation of Tropheryma whipplei****** (I had some difficulties as you will notice)

JJ

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REFERENCES:
"Whipple Disease", StatPearls (2020)
www.ncbi.nlm.nih.gov/books/NBK441937/

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Although I try my best to present accurate information, there may be mistakes in this video. If you do see any mistakes with information in this lesson, please comment and let me know.
All Comments (19)
  • @Patricia-yn3hu
    My sister died from this. Doctors kept telling her it was celiac disease, but she was only getting worse. It wasn't until she died from cardiac arrest that we found out it was whipple disease. She was only 32. It's devastating.
  • @aurorarose2836
    Intetesting, I've never heard of this disease...and I farm😨.
  • @doctorshakeel9442
    Arthralgia first... Then followed by Gastro intestinal symptoms such as chronic diarrhea, bloating , protein losing gastropathy leads to Nuerological symptoms such as Ataxia etc , pericarditis etc...
  • @julianfalciola5237
    Won't 1 Year of Antibiotics lead to the patient having Pseudomembraneous Colitis? Also literature on Pubmed also found that some Patients with Whipples had constipation whilst other had diahreah
  • @dailydoseofmedicinee
    The most common signs and symptoms of Whipple's disease include:👇 chronic joint pain. chronic diarrhea that can be bloody. significant weight loss. stomach pain and bloating. decreased vision and eye pain. fever. fatigue.
  • @robertam2785
    Minha mãe está internada, o médico descobriu há uma semana esta doença, iniciaram os antibióticos pois estava com diarreia crônica e muita desidratação, e o nível de proteína está tão baixo que ocasionou edema pulmonar. Agora estão administrando diuréticos para reduzir o enema. Moramos em Vitória, ES, Brasil.