Cholinergic Crisis vs Myasthenic Crisis Nursing | Symptoms, Treatment, Tensilon Test (Edrophonium)
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Published 2017-12-04
CORRECTION: At 8:28, when I discuss Edrophonium it should say that Edrophonium = acetylcholinesterase inhibitor (which is a cholinesterase inhibitor) NOT ANTIcholinesterase.
Cholinergic crisis and myasthenic crisis are two complications that can happen with the neuro disease myasthenia gravis. The causes of each condition are different along with some of the signs and symptoms. However, both conditions will share the sign and symptoms of respiratory failure and severe muscle weakness.
A tensilon test (administration of Edrophonium: which is an cholinesterase medication) can help differentiate between the two conditions. If a patient is experiencing a cholinergic crisis, the tensilon test will show a negative result in that the patient’s signs and symptoms will worsen. However, if the patient is experiencing a myasthenic crisis the test will show a positive test result in that the patient's signs and symptoms will improve temporarily.
The cause of myasthenic crisis is NOT receiving enough of an anticholinesterase medication (example Pyridostigmine) or an acute exacerbation of the disease myasthenia gravis due to stress or respiratory infection.
The cause of a cholinergic crisis is receiving TOO MUCH of an anticholinesterase medication.
How do anticholinesterase medications work? They stop the breakdown of acetylcholine at the neuromuscular junction, which allows more ACh to be available at the junction. This is great for treatment of myasthenia gravis. However, if too much of this medication is given it will cause a cholinergic crisis, but if not enough is given it will cause a myasthenic crisis.
Cholinergic crisis vs Myasthenic Crisis Quiz: www.registerednursern.com/cholinergic-crisis-vs-my…
Notes: www.registerednursern.com/cholinergic-crisis-vs-my…
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All Comments (21)
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*CORRECTION*: At 8:28, when I discuss Edrophonium it should say that Edrophonium = acetylcholinesterase inhibitor (which is a cholinesterase inhibitor) NOT ANTIcholinesterase inhibitor. I hope this video helps you with your studies! Thank you for watching it. Don't forget about the free resources: Quiz: www.registerednursern.com/cholinergic-crisis-vs-my… Notes: www.registerednursern.com/cholinergic-crisis-vs-my… More Neuro Videos: https://www.youtube.com/watch?v=x2xETKT9-4o&list=PLQrdx7rRsKfVPDxuXWcpmg42nNXdjA9FD Instagram: www.instagram.com/registerednursern_com/ Facebook: www.facebook.com/RegisteredNurseRNs Twitter: twitter.com/NursesRN
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This is 10minutes after finding out I passed my nclex at 75 questions. I HAVE to come to Sarah's channel to thank her. Other than doing practice questions and reviewing my own notes, this youtube channel was my number 1 source of review. I only wished that I had her videos two years ago when I started my nursing program to save me from all the struggles. ALL current/future RN-students are so lucky to have you Sarah.
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My Mom was recently diagnosed with myasthenia gravis. I am watching every single bit of info I can get! Thank you for this video ❤️
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Dear Ms. Sara, I would like to express my gratitude for helping me to pass my NCLEX exam.Your videos really really helped me a lot throughout my nclex review. You are a blessing to many. Thank you very much Ms. Sara. May God bless you always 🙏🏻🤗💐 Yours truly, Nicole
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Hey sarah, i've already aced my NCLEX since last year but i still love watching your vids. My daughter is now in her third year in nursing and i also recommended for her to follow your vids. Thanks a lot!
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Maam. I passed my DHA nursing exam with the help of you videos. It such a big help :) thank you from the Philippines :)
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one of the finest explanation in a very simple yet effective way.. thanks a lot.
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Thank you for this! My husband suffers from MG, and this is a great video to share with my fellow responders and intake RNs just to brush up on the basics of this debilitating disorder.
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wow I watched so many videos on this and this one helped it all "click" in my brain, you explain in an easy, clear way, thank you.Also I am a nursing student at Orlando, Fl in my 1st year and all my classmates reference your channel for clarification on a topic.
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You did an amazing job explaining this topic! thank you!
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Thanks a lot you make complicated concepts so easy!
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Perfect explanation, nice, easy, and simple! BRAVO!
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You are the 🐐 this made so much more sense than reading my lecture slides!
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Thank you .you are a blessing
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Thank you very much for your video. It really helps me to prepare for my final.
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Great lecture and quiz
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Great job with breaking it down to the simplest terms and highlighting the important parts for NCLEX. I truly have enjoyed watching your videos, please keep them coming
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Nurse Sarah, you are the answer to my prayers! Can I get an AMEN!
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Love love your pathophysiology videos! You have no idea how much you've helped me! Your tying in of patho with interventions and s/s is just amazing. You should be a Professor!
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Thank you! I love your videos. I wish you would make a playlist with stuff for peds.
