New Research: Sialic Acids May Contribute to Inflammation & Disease

Published 2021-05-13
Dr. Roger Seheult of MedCram explains new research on Neu5Gc, a sialic acid molecule found in meat and dairy, and how it may contribute to severe COVID-19 symptoms, inflammation, and certain chronic diseases and cancers.

Roger Seheult, MD is the co-founder and lead professor at MedCram www.medcram.com/?utm_source=Youtube&utm_medium=Vid…

He is Board Certified in Internal Medicine, Pulmonary Disease, Critical Care, and Sleep Medicine and an Associate Professor at the University of California, Riverside School of Medicine.

Interviewer: Kyle Allred, Physician Assistant, Producer, and Co-Founder of MedCram.com

This video was recorded on May 13, 2021

TOPICS IN THIS VIDEO INCLUDE:

00:00 Introduction to sialic acids and why they’re important
00:39 What are sialic acids?
01:53 Introduction to Neu5Ac (in humans) & Neu5Gc (in other mammals)
03:41 Why are Neu5Ac and Neu5Gc important?
05:41 Human antibodies against Neu5Gc-glycans, chronic inflammation, & xenosialitis
07:21 French NutriNet-Sante study and “Gcemic Index” of foods
08:40 Does just red meat contain Neu5Gc? What about poultry, eggs, & fish?
09:14 Neu5Gc intake differences in men & women
10:26 Association between BMI, plant-based diets, & sialic acids
13:02 Cycle of obesity & inflammation
13:30 Biologic therapy & coronary inflammation
14:51 Dr. Esselstyn’s work on diet & coronary artery disease
16:01 Risks of meat consumption - processed versus unprocessed
20:00 Health benefits of red meat consumption
22:01 Summary of diets & associated outcomes, looking ahead to COVIDENCE UK Study

LINKS / REFERENCES:

Mechanism of uptake and incorporation of the non-human sialic acid N-glycolylneuraminic acid into human cells (Journal of Biological Chemistry) | pubmed.ncbi.nlm.nih.gov/15557321/

From “Serum Sickness” to “Xenosialitis”: Past, Present, and Future Significance of the Non-human Sialic Acid Neu5Gc (Frontiers in Immunology) | www.frontiersin.org/articles/10.3389/fimmu.2019.00…

Association between Neu5Gc carbohydrate and serum antibodies against it provides the molecular link to cancer: French NutriNet-Santé study (BMC) | www.ncbi.nlm.nih.gov/pmc/articles/PMC7510162/

Adventist Health Study-2 (Loma Linda University Health) | adventisthealthstudy.org/studies/AHS-2

Association of Biologic Therapy With Coronary Inflammation in Patients With Psoriasis as Assessed by Perivascular Fat Attenuation Index (JAMA) | pubmed.ncbi.nlm.nih.gov/31365032/

A plant-based diet and coronary artery disease: a mandate for effective therapy (Journal of Geriatric Cardiology) | www.ncbi.nlm.nih.gov/pmc/articles/PMC5466936/

Meat consumption and risk of 25 common conditions: outcome-wide analyses in 475,000 men and women in the UK Biobank study (BMC) | bmcmedicine.biomedcentral.com/articles/10.1186/s12…

The COVIDENCE UK Research Study has been developed in response to the outbreak of coronavirus disease (Queen Mary University of London) | www.qmul.ac.uk/covidence/about-the-covidence-uk-st…

All coronavirus updates are at MedCram.com (including more discussion on: does red meat cause cancer, cardiovascular disease, sialic acid, dairy and red meat cancer, COVID 19 Vaccines, and more).


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#COVID19 #SialicAcid #Neu5Gc

All Comments (21)
  • @Medcram
    See all medical videos by Dr. Seheult (the professor in this video) at his website: www.medcram.com/collections?category=courses If you haven't already done so, please subscribe to this channel to get notified of new videos. Thank you for your support
  • I find this ironic. I was mostly plant based for years (no processed) and was never any sicker. Went to grass fed meat, raw milk some eggs, and one cup of vegetable a day and I've never been better. I was so inflamed, thought I was dying. Animal based diet saved my life.
  • @davidplyler8173
    One man's experience, eating a mostly beef diet has reduced joint inflammation, improved my skin, lost fat, gained muscle, stopped snoring, lower blood pressure and more. Going on 17 months now I feel and look and perform better than I have in 20 years. When I got covid it was nothing except my steak didn't have much flavor. I'm 63. I forgot to mention one of the MAIN benefits I've had, my reflux has completely gone away. I used to have to sleep with the pillows propping my head up so the reflux wouldn't burn my throat. Guys I'm all for studies but they need to study mostly beef, there's enough of us doing this now. I'll volunteer.
  • Can anyone confirm from the studies HOW the meat and dairy was consumed? There's a massive difference between meat eaters, who consume large amounts of sugar and processed foods (high carb, low quality meat, usually paired with seed oils), and carnivores who ONLY consume meat (low/zero carb, high quality meat). Can anyone confirm?
  • @avader5
    Tell that to my grandma she ate meat cheese and bacon all her life she lived to be 107 years old. My girlfriend switched to a low carbohydrate meat and vegetable program and reversed her type 2 diabetes.
  • @dinaarmeni2674
    I would like to know what % of the meatveaters also were heavy sugar/carb eaters, as sugar is inflammatory
  • @vgernyc
    My complaint about the "non-vegetarian" study is it does not differentiate someone who eats processed/fast foods from someone who avoids those foods or is on a paleo or keto diet.
  • @tubeysr
    For someone who's both parents died of Cancer, this is important to me. Thank you 💚
  • @karimayoubi74
    Hi Medcram. Do these studies successfully control for healthy & unhealthy user biases? Someone who is consciously choosing their diet (be it vegetarian, vegan, pescatarian, ovolactoid or whatever) is likely to be more health conscious in other ways. Meanwhile a red meat eater could be someone who eats McDonalds or equivalent junk every day, or it could be someone who is choosing organic, unprocessed meat 3x a week as part of a consciously healthy lifestyle. Our health expectations for these two would be radically different! Do these large scale epidemiological studies control for these important differences within groups?
  • @windsongshf
    Oh great. I've done everything from fruitarian to carnivore. Now what do I eat?? Lol! When I went Carnivore I lost 20 pounds and was able to throw away both my anti-depressants and anti inflammatory pain relievers. Guess I'll die no matter what. Ug.
  • @marygem
    When will they examine sugar, seed oils and gmo flours? Also, he carefully avoided any actual stats.
  • @robzee67
    Big fan of the channel. I do have to share that since being on LCHF, I almost brought my CAC score to zero from a higher level and my lipid profile completely reverse it self! My cardiologist wanted to put me on statin. I did eliminated sugar completely from my diet and exercise vigorously. (I have 3 years of blood work and cac score results if you want to see them) Thank you for your channel and everything you do to explain clearly and simply!
  • @FearIsaLiar
    I give you credit for keeping me from ever catching Sars Cov 2. I'm a Registered Nurse with extensive exposure early on yet I never got sick. I do take your recommended list of supplements. Your an American Hero
  • I am a doctor with a special interest in nutrition. In this video 4 diets are compared and the conclusion is suggested that the diets containing meat are the cause of inflammation and other diseases, due to the fact that meat and other animal products contain Sialic acid. I would contend that this is hugely flawed conclusion! FIRSTLY, one has to ask, what does average meat eater in the USA and other western countries eat, besides the meat? Answer, huge quantities of sugar, refined carbs and the omega 6 (inflammatory) oils. The Standard American Diet. (SAD). I contend that it is these factors which are the drivers of insulin resistance, leading to metabolic syndrome, inflamation and a wide spectrum of related diseases, and not good quality animal products themselves. Space does not allow an in-depth explanation but I invite you to look at the low carb (keto) lifestyle. My personal journey to health is an another whole story.
  • @tomasranta6154
    Dr. Chris Knobbe might say that much of the disease you point to rarely occurred before the early 1900’s. That’s when seed oils became readily available. I would like to hear your ideas on his work or the idea that chronic diseases really took off then.
  • @fignewton8690
    Is this associated with a high carb intake? In other words if someone is keto and fat adapted (and do not consume sugar) is the process still the same?
  • Association is not causation. These studies are based on diet recall questionnaires and association only. Usually not taking into consideration other lifestyle factors. I would be interested in who funded these studies.
  • It’s not in seafood or poultry though, but still need to make sure not to eat poultry fed lectin rich or genetically modified grains etc
  • @lajana23
    Moderation. I'm always skeptical when the focus narrows to one thing. Too many factors, not enough empirical data
  • @GeneGerwin
    I appreciate the level of science behind your videos. In depth enough that us laymen always learn something new without feeling lost in jargon.