Inside ALS: The neurons behind the disease

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Published 2017-04-21

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that mainly affects the nerve cells (neurons), which control muscle movement. As the motor neurons degenerate, they stop sending signals to the muscles, causing progressive muscle weakness and — ultimately — death. This animation focuses on the mechanisms within the motor neurons that cause them to degenerate. By understanding these mechanisms, researchers hope to one day find a cure for ALS.

To learn more about ALS, check out the Primer: www.nature.com/articles/nrdp201771
and the PrimeView: www.nature.com/articles/nrdp201772

Nature Research has full responsibility for all editorial content, including Nature Video content. This content is editorially independent of sponsors.

All Comments (21)

@AdventureDaksExplores 4 years ago

My mom have this ALS since 2007 to present. the doctor said before she's only got 3years and luckily she's with us until now. 12years since then and i hope more and more years to come for my mother :'(
@RolandMoone 7 years ago

This is literally the best channel I've ever come across on Youtube. The amount of detail and the visual complements are just incredible.
@reshmaangela8584 3 years ago

This is so informative... And reminds us being actually functioning and normal is a gift😭
@emilytarter7014 4 years ago

I lost my nana, 3 years ago. I’m proud of who my nana was and i strive to carry on how she stayed positive threw 12 years of als. I will always love u - ur pixie
@dani010203stor 2 years ago

i hate this disease so much. Its SO sad, for the person who suffers is and to the people who loves them. Its literally a torture, it makes me so mad
@maelleamand 1 year ago

Thanks to the person doing the voiceover and for the entire team behind the video!
@Jimmyeatshrimp 3 years ago

Thank you this is literally the world's best animated and explained video ever I wish you and the creators of this video everlasting health and happiness may your families and grandchildren live long fulfilling lives because you deserve the world and nothing less. I love you.
@vidusia1634 3 years ago

My mother was diagnosed with ALS about 2yrs ago. Watching her suffer is the hardest part. Through each stage everything gets harder and harder and it hurts k owing that theres nothing you can do but watching them die slowly. 💔
@philkyaw9479 2 years ago

THIS IS SO HELPFUL The amount of detail, smooth animation and information makes this very helpful for this school project i am doing on MND/ALS
@onemoremarble 4 years ago

This disease is so complex, I understand why they are battling to find a cure or a treatment. Good concise summary.
@aidenblack8930 7 years ago

All I know is that Mitochondria is the power house of the cell
@alondragutierrez2280 3 years ago

this shit killed my grandma it was the most saddest death i've ever seen. I loved her so much.
@miiaaalvarez 4 years ago

This is one of the best biology videos ever
@user-qc6gs4qu8g 3 years ago

One of my committee professor died of this disease yesterday. May the soul Rest In Peace.
@Electroblade360 2 years ago

The Animation Is Extremely Easy To Praise
@Chevalier2211 7 years ago

I'm happy because everyday more people are searching for a cure for ALS. Thanks Nature for your video, was very illustrative.
@mohammadabouleil6745 3 years ago

My dad had it from 2002 till 2004... past away from it.
@meganmalicki9857 7 months ago

My Grandmother got ALS. She had 4 children. 3 of the 4 have ALS, including my Dad who was just diagnosed on Monday.
@izzylush481 5 years ago

This is amazing thank you
@user-zr9ks2wp5l 7 years ago

is there any videos illustrating medical basics in such adorable manner ?