The Key Genetic Factor in Alzheimer's: APOE4 Gene 🧬🧠

This is a very informative and reassuring discussion. I believe that for me, learning I'm homozygous apoE4 (over 5 years ago) has been beneficial, particularly after I learned that you have cared for 4/4's with advanced age who exhibit no signs of dementia. I feel very lucky that I can exercise vigorously, and I enjoy the challenges it brings, as well as enjoy following a WFPB diet since 2008. I have found the silver lining of my diagnosis: greater motivation to consistently make the lifestyle choices that are beneficial for basically all humans. Attending my 50th HS reunion last month, I realized that I was one of, if not the very healthiest of all my classmates. It felt so good to dance to the live band playing old rock tunes. I had so much energy and joy pouring out of me. It was my ideal way to celebrate my luck to be alive and thriving after 50 years. Thank you for your guidance and support!

Isn’t that the risk of dementia among people with Apoe4 is much higher because of the milieu modern humans are living in? I mean low fat high-carb processed diet, eating 6-8 x a day etc? People with Apoe4 should all the more stick to ancestral diet

❤ this is absolutely excellent! Thank you so much. Alzheimer's and Dementia are all over my family and I'm already seeing elevated levels of phosphorylated towel in my blood test. I am grateful that you guys took the time to put this video together.

Thank you for explaining so clearly! Especially the details of what exercize actually does in the different areas of the body 👍😊

Very informative and motivating to adjust our lifestyle to minimise our risk of developing dementia and improving our overall health. Thank you for explains it all so clearly 🙏

Thank you, this was so relevant and informative.

So thankful for this broadcast and the hope regarding how lifestyle impacts APOE4. There is so much fear surrounding this gene; it is so welcome to hear actual steps (i.e. physical exercise and reduction of saturated fats) and recommendations for what to do. Wondering whether increasing DHA supplementation or polyunsaturated fats as mentioned poses a risk of increasing cholesterol and what your thoughts are about this for the APOE4 individual? I am also wondering whether medication that focuses on the reduction of plaques and tangles is focusing on the wrong thing? It would also be great to hear your thoughts about BHRT in peri and menopausal women as well as pregnenolone for brain health.

The most comprehensive explanation of the complexity of dementia therefore the difficulty in finding the root causes. Fascinating information regarding birds.

I'm 35 years old and carry a copy of ApoE 4. I run about 10-13 miles per week, minimize carbs and processed food, and I eat sardines and salmon at least 5 times a week. I also supplement with krill oil. I have not had a drink of alcohol in a while, though I'm not enthused about giving up wine. My question: what is the cost-benefit analysis for small amounts of alcohol? Is it even worth the risk for an ApoE 4 carrier?

From what you both have said a daily allowance of 1 gram of DHA and 1 gram of Omega 3 per day would be a good amount - am I correct here. Since all of my immediate family died of dementia I am very interested in this topic. I already know that I have 2 copies of APOE4. Thank you so much for doing these videos.

I am just beginning to understand and research APOE4. I appreciate the help. My internal medicine Dr keeps throwing it at me verbally, but I had no idea what he was talking about. Family of diabetics, high cholesterol, and vascular dementia, and hypopnoea. Dr pushing pills, and I'm trying to fix without prescriptions.

Perilla oil has some good studies on APOE4 knockout mice and also on elderly Japanese with very good effects on cognition. Perilla is extremely high in ALA.

This is great information for those who are familiar with these medical terminology, scientific names and reading, not to those who are ordinary people like those of us who are following you two for simplification down to earth vocabularies. If my knowledge was at your level, I would have not listen to you or follow you. Please make these information to the level of your audience? Greatly appreciate your time and knowledge!!!

I read this somewhere in clinical trials which read “Problem is EPA conversation to DHA in nuts and seeds is very poor hence the fish or fish oil or supps “

Regarding high LDL - I have heard many doctors who believe that more important is the ratio of Triglycerides to HDL . High HDL and lower Triglycerides being okay. Excellent video - Diet could have been included in talk - I will now eat more fish because of the Omega 3's and lower red meat!! You mentioned William Huf who I love...He has given some good advice in regard to breathing exercises...cold showers not for everyone, Brrrr! I searched hard and finally found that he is a vegetarian.

Can you speak to A2 dairy with APOE4? Good, bad?

With APOE4, could citrus bergamot supplements be beneficial?

This is anecdotal, but after having months of chronic fatigue syndrome (after 6 rounds of IVF drugs), the sauna was the only thing that helped me get better & how I regained my strenght.

You said that APOE4 carriers should reduce LDL but didn't really say why. Cold you please clarify and state the main studies etc

Not that it is a big deal, but you appear to be in mirror image. Thanks for this info. I know you would get 100 times the views if you were downplaying saturated fat and ldl (and perhaps selling berberine), I appreciate the integrity.