Can someone with an APOE4 genotype follow a ketogenic diet? | Dominic D'Agostino

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Published 2022-05-11
The ketogenic diet is contraindicated in people with pancreatitis, fat metabolism disorders, and other rare metabolic conditions. Some people carry a version of the apolipoprotein E gene called APOE4 – a risk factor for late-onset Alzheimer's disease. This gene variant affects fat metabolism and distribution to the brain. Dr. D'Agostino questions whether a high-fat ketogenic diet is suitable for people carrying an APOE4 gene variant. He suggests it may be prudent to select a more liberalized version of the diet and gradually restrict carbohydrates and monitor biomarkers for adverse reactions. Other thoughts include incorporating fiber-rich vegetables and choosing unsaturated rather than saturated fats. In this clip, Dr. Dominic D'Agostino discusses the applicability of a ketogenic diet for people with an APOE4 gene variant.

Interview published on April 28, 2022

Watch the full interview:
   • Dr. Dominic D'Agostino on Developing ...  

#Ketogenic #Diet #Metabolism
All Comments (8)
  • @ken3marcus
    What is the study reference or mechanistic evidence regarding saturated fat and APOe4 ?
  • @rongqut7576
    What is "high in fat and super restrictive" mean? High in what fat? "Super restrictive" refer to what food? Meat? Or fibre? Or Carbs?
  • @TheJaYSolo
    To Dr. Patrick & Dr Agostino, I desperately request your input on this question. Can a person with APOE 3/3 have familial high triglycerides? I ask because everything I find about 3/3 shows that it's the most common and it's the genotype that has normal lipid metabolism. So does abnormally high triglycerides in patients with 3/3 not hereditary? Is this conclusive that it's not familial and by default must be lifestyle or other factors since apoe 3/3 is a genetic test? I really need this information for my own case and I hope any of you amazing Doctors gets this message and gives any input as it will help me tremendously!!! I literally BEG of you both
  • @TheTibo13
    It would be much more interesting if someone who has these familial Alzheimer's genes (Psen1 etc.) can follow a ketogenic diet
  • @zanetahulist
    My genetics says that ketogenic diet give me inflammation I gave 2 copies What to do ;(
  • @philw9120
    So the most ancient genotype APOE4 which developed when we were eating exclusively meat (which is 50% monounsaturated BTW) and we thrived enough on it to pass the gene on to 25% of today's population is somehow now bad for APOE4 types? Oh and keto is scary say's the trillion dollar statin industry, even though we are born in ketosis, our natural state. And somehow we can't get enough selenium if we don't eat carbohydrates. This guy surely got his nutritional education from a comic book, or the AMA which is comparable.
  • @williamhenry3337
    I am a ApoE2 (E2/E3). I wish someone would talk about people with E2. There is almost no information on E2.