DNA Replication (Updated)

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Published 2019-06-28
Explore the steps of DNA replication, the enzymes involved, and the difference between the leading and lagging strand! This video is an update from our old DNA replication video with nearly the same script but added detail and improved art! See table of contents by expanding details.

Table of Contents:
00:00 Intro
0:11 Why do you need DNA replication?
0:27 Where and when?
1:12 Introducing key player enzymes
2:48 Initial steps of DNA Replication
4:04 Explaining 5' to 3' and 3' to 5'
5:09 Showing leading and lagging strands in DNA replication

Video has a handout here: www.amoebasisters.com/handouts

Factual Reference:
OpenStax, Biology. OpenStax CNX. May 8, 2019 cnx.org/contents/185cbf87-c72e-48f5-b51e-f14f21b5e….

**Further Reading Suggestions**

-More info about prokaryote vs. eukaryote DNA Replication? (Which video doesn't go into) Check out the bottom of this page of the peer-reviewed, FREE OpenStax testbook: cnx.org/contents/[email protected]:2l3nsfJK@5/DNA-Rep…

-More detail about DNA replication, including the different types of polymerase? Check out this page of the peer-reviewed, FREE OpenStax textbook: cnx.org/contents/[email protected]:NEk9ll-3@8/DNA-Rep…

-Check out this science paper that details how cancer drugs can work to stop DNA replication in cancer cells. www.ncbi.nlm.nih.gov/pmc/articles/PMC5797825/

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Want to learn tips for viewing edu YouTube videos including changing the speed, language, viewing the transcript, etc? www.amoebasisters.com/pinkys-ed-tech-favorites/10-…

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Our intro music designed and performed by Jeremiah Cheshire.

End music in this video is listed free to use/no attribution required from the YouTube audio library youtube.com/audiolibrary/music?feature=blog

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We take pride in our AWESOME community, and we welcome feedback and discussion. However, please remember that this is an education channel. See YouTube's community guidelines and how YouTube handles comments that are reported by the community. We also reserve the right to remove comments.

TRANSLATIONS:
Hindi Subtitles Credit: Alisha Aggarwal

Some translated subtitles on our videos were translated by the community using YouTube's community-contributed subtitle feature. After the feature was discontinued by YouTube, we have another option for submitting translated subtitles here: www.amoebasisters.com/pinkys-ed-tech-favorites/com… We want to thank our amazing community for the generosity of their time in continuing to create translated subtitles. If you have a concern about community contributed contributions, please contact us.

We have videos dubbed in Spanish and Portuguese using an artificial voice via aloud.area120.google.com/ to increase accessibility. See our Amoeba Sisters en Español channel    / @amoebasistersespanol   and Amoeba Sisters em Português    / @amoebasistersportuguese  

All Comments (21)
  • @AmoebaSisters
    UPDATE: We have videos dubbed in Spanish and Portuguese using an artificial voice via aloud.area120.google.com/ to increase accessibility. See our Amoeba Sisters en Español channel www.youtube.com/channel/UC1Njo3LBy53cOPngz6ArV8Q and Amoeba Sisters em Português www.youtube.com/channel/UCYTQPX2X_mXe0ZMPi0fXxbg Want to help translate our subtitles in any language? Learn more here www.amoebasisters.com/pinkys-ed-tech-favorites/com… We hope you like our newly updated DNA replication vid! So what's different? You will find the script to be almost the same, except with a little more detail: we included topoisomerase activity and better explained leading and lagging strands. (Again, remember, there is still much detail to explore beyond this video!) Our art has also improved as we continue to practice and no MS Paint this time ha! You can see our milestones here: www.amoebasisters.com/milestones.html Also, no worries, we try to not delete old videos. The old DNA replication video, if you prefer it, is still here: https://youtu.be/5qSrmeiWsuc
  • @ashleygrey7986
    The fact you made a 11 minute video to explain what my teacher explained in 2 hours....
  • @davet4335
    Me, 82 year-old, high school grad, fascinated, self-educated, life-long learner...loving you for your amazing work.
  • As a medical student, I love this woman, always saving my life with these amazing videos. THANK YOU
  • @amsd5780
    I just love how the audience is growing up with the videos, a few years ago we were all doing either IB or AP and now we're coming back to this in college. Thank you for raising us amoebas! :D
  • @warwick802
    Me in Middle School- Laughing at these videos. Me in High School - Appreciating these videos for saving my life to prepare for exams. Me in College: Literally thanking these videos for saving my entire degree.
  • @kennethng7922
    That moment when realize you're already in gradschool and still watching this to prepare for exams
  • @xDjiki
    I wish I’d watched this before I got a C on my biology exam… which I today gotta correct to an A. The fact you were able to explain this whole process in 8 minutes and my teacher couldn’t in literal HOURS of lessons is just amazing. Props to you!
  • @Selenanina19
    It's the way that I'm finished with my first semester of uni and my professor never explained why and how DNA polymerase only goes in a 5 prime to 3 prime direction. I learned an entire semester of biology in this one video and I'm beyond grateful or else I would have failed my exams. ㅠㅠ Thanks so much for the awsome video!! <333
  • @dunebuggy3262
    learned more from this than from my teacher with a PhD
  • @vish850
    This really helped me with the whole lagging strand thing.
  • @alleycat1217
    Right now, I’m a 9th grader studying for an honors bio unit exam, but I have a feeling I’ll be coming back to these videos in college! Your videos are always super helpful, especially for me since I’m a visual learner and struggle to understand concepts without pictures and graphics. Please keep doing what you’re doing! Update: I got a 98 on my exam! Thanks so much Amoeba Sisters!
  • @alnimri
    I remember my 9th-grade biology class using these videos to teach us. Currently reviewing for a DNA test in a college Microbiology class. Still just as useful as ever!
  • LITERALLY GOT A MICROBIOLOGY EXAM TOMORROW AND WATCHED THESE IN HIGH SCHOOL BUT STILL HANDY IN COLLEGE
  • This video literally helped me out for a test I have tomorrow. I didn't get a thing the teacher said while I was in class and yet I paid attention. The simplicity and clarity that this video had, made me forget that this test was going to be hard. It literally took all my stress out just seeing that it's that simple (I know it's more complex but I got it). Props to the ones who created and edited this video. You made my day. Keep it up :)
  • I love the way she uses these little game characters to explain it. Really helps. ❤
  • @byuchu454
    Amoeba sisters: exist My science teacher: Y. E S
  • @tkurthyt
    why am i paying a university to test me on this when you can watch it on youtube for free....
  • The 4 horsemen of DNA replication: -Dna polymerase -Helicase -Primase -Ligase