Vitamin D reduced dementia by 40%

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Published 2023-03-13
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Vitamin D supplementation and incident dementia: Effects of sex, APOE, and baseline cognitive status

alz-journals.onlinelibrary.wiley.com/doi/10.1002/d…

Alberta, Canada

Known association, vitamin D deficiency, incident dementia

nutritionj.biomedcentral.com/articles/10.1186/s129…
Role of supplementation is unclear.

Prospectively study

Associations, vitamin D supplementation and incident dementia

N = 12,388 dementia-free people

(from the National Alzheimer's Coordinating Center)

Methods

Baseline exposure to vitamin D was considered D+

No exposure prior to dementia onset was considered D−

MCI and depression were both more frequent in the D− group, compared to D+

People taking vitamin D had less MCI and less depression

Adjusted for age, sex, education, race, cognitive diagnosis, depression, and apolipoprotein E (APOE) ε4.

Potential interactions between exposure and model covariates were explored.

Results

Across all formulations,

vitamin D exposure was associated with significantly longer dementia-free survival,

and lower dementia incidence rate than no exposure

Hazard ratio = 0.60

(95% confidence interval:
0.55–0.65)

Vitamin D exposure was associated with 40% lower dementia incidence versus no exposure.

Over 10 year follow up of

12,388

2,696 participants progressed to dementia

Among them the 2,696

2,017 (74.8%) had no exposure to vitamin D

679 (25.2%) had baseline exposure

Exposure to vitamin D was associated with significantly higher dementia-free survival

5-year survival for D− was 68.4%

5-year survival for D+ was 83.6%

The effect of vitamin D on incidence rate differed significantly,

Vitamin D effects were significantly greater in females versus males

Vitamin D effects were significantly greater in normal cognition versus mild cognitive impairment.

Vitamin D effects were significantly greater in apolipoprotein E ε4 non-carriers versus carriers.

Vitamin D effects were less significantly apolipoprotein E ε4 carriers. (25% one copy, 3% two copies)

Vitamin D has potential for dementia prevention, especially in the high-risk strata.

Vitamin D deficiency, worldwide prevalence of up to 1 billion.

www.sciencedirect.com/science/article/pii/S0002916…

Mechanism of action

www.nature.com/articles/s41430-020-0558-y

Vitamin D is known to participate in the clearance of amyloid beta (Aβ) aggregates,

one of the hallmarks of Alzheimer's disease (AD),

and may provide neuroprotection against Aβ-induced tau hyperphosphorylation

(neurofibrillary tangles)

Cholecalciferol may be more effective than ergocalciferol

All Comments (21)
  • My mother died from Alzheimer's, she never ever ever went outside to get sun nor took sups. By comparison, her brother is still running the family farm at almost 90 years old. Healthy, tanned, and strong
  • @wyattsgrammy
    You can't know how much this video has meant to me. My mother and her sister both died with Alzheimer's. As did their material aunts. Their mother died of uterine cancer before she was old enough to develope it. I have stage 3 kidney disease and was placed on D3 eight years ago because of that. I am 71 and have worried for a long time that I would definitely develope Alzheimer's. You have given me hope. Thank you for all you do.
  • @karmakat66
    I find this so depressing I worked as a mental health nurse in Dementia care for over 20 years, latterly I used to bang on about Vitamin D supplementation to our Consultant Psychiatrist for all our elderly care home patients , they never saw the light of day ! The psychiatrist thought I was quite 'out there' I became totally disillusioned with the lack of interest in this area of mental health, the overuse of sedatives and pointless medications. There was a small cohort of patients that got Melatonin and I still believe this is another hugely overlooked hormone that has multiple benefits. I retired early from nursing as I wasn't doing any, I was sat behind a desk typing pointless care plans and sitting on a phone trying to get emergency care packages that were never enough. The system is totally broken.
  • I am a caregiver, I have a patient I have been taking care of for a year and a 1/2 with dementia. I have been giving this patient Hide doses of vitamin D for a year now, and have noticed vast improvements with their Speech and memory. They don't lose their train of thought nearly as often and don't seem to be "lost" as much
  • @kathyevans110
    My husband started taking D3 daily last year. In Dec. '22, out of the blue, he started saying that he is thinking more clearly and his recall abilities have improved. (He's 62 and has had a horrible memory for years) He and I are RNs and had no idea that this was a "thing". Thank you for finding and reporting on this study.
  • @nota8386
    I can't think of a channel on YouTube that provides as much value to its viewers.Thanks Dr Campbell, you have impacted the lives of thousands of people in positive ways.
  • @koenraad4618
    I am a 60 years old, two years ago I started a daily vit D capsule, during the winter and spring months. This reduced my yearly common colds to almost nothing, and now this! Thank you Dr Campbell for spreading this information. Vit D is also recommended for MS patients, my wife has a light non-progressive form of MS, and the hospital subscribed vitamine D. It clearly improves the health of the nervous system and our immune system.
  • Thank you John for sharing this data. Taking vitamin D regularly would save so many individuals and families the devastation, heart break and financial loss that dementia causes. Anyone who has seen it up close knows what a life shattering effect it causes to the person who has it and their family members. Sugar and too many grains, flours also contribute to this by causing insulin resistance - the silent cause of so many health issues.
  • @jdelbrid
    My mother was paranoid about getting skin cancer, so she would not go outside without being fully covered. Later in life, she covered her windows to keep out sunlight. She died with severe dementia.
  • @JudyHart1
    Found an old lab result from 2016 the other day, my Vitamin D was 28, last result was 89, thank you Dr. John.
  • It’s wonderful how you are funding these practical health care interventions in Uganda. As others have said before, you truly are a hero.
  • I’m 73 I take Vitamin D since covid starter, k12 thanks to you, cod liver oil, turmeric for arthritis. All good sense thanks Dr John ❤
  • @shardlake
    Great study, such a cheap and simple option. Certainly been taking D3 and K2 ever since discovering your channel at the beginning of the pandemic. Although purely anecdotal, had fewer colds, and even after finally getting Covid in December 22, it was 3 days of aching joints and stuffy nose. I worry that our governments are really not concerned with keeping us healthy unless their is money involved, keeping us around for longer is not top of their list.
  • @chrish8487
    Hi Dr. Campbell, nurse practitioner here. I have frequently educated many of my patients about the myriad of health benefits associated with maintaining optimal vitamin D levels, and this longitudinal study from Canada is quite eye-opening. Thank you for all the wonderful work you provide, and I pray for your continued health and willingness to advocate for interventions that truly benefit people worldwide 👏
  • Thank you so much Dr. Campbell. All your love, time and efforts are always appreciated! That's what the health profession should be all about, making a positive impact on people's lives. 🙏❤️
  • @lin9391
    my parents are 87 and 92 living in their own home, driving, playing cards, shopping etc. its been probably 50 years ago we all started taking vitaminD3 when i (69) read somewhere it helps with depression. so happy to hear you talk about this Canadian study. it is sad that some people were not given D3 for 10 years to prove this point but God bless them.
  • @mfdixon2265
    My cousin,who had deep vein thrombosis, was told by his doctor to take Vitamin D. The doctor found that most of his patients with DVT were vitamin D deficient.
  • @thesonhaslife
    Thank you Dr. Campbell for all you do . I pray more people start critically thinking for themselves . 👍
  • Alzheimer’s and dementia are both prevalent in both sides of my family starting around age 70. I I’ve been worried about this for many years. I have a vitamin D regiment that I take every day, but this is reassuring that I am doing the right thing for myself and my family going forward. I will share this video and study with everyone I know affected by this. Thank you for this!
  • @CatsGoMoo100
    Thank you for what you do John. This is such valuable and laudable work. Given away for free, with humility. Thank you.