How COVID Kills Some People But Not Others - Doctor Explaining COVID
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Published 2020-04-15
Welcome to another video; I'm Doctor Mike Hansen; I am a real doctor specializing in pulmonary medicine, critical care medicine, and internal medicine for those who don't know me.
Verify my board certification status:
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When I'm not working in the hospital or pulmonary clinic, I'm at home making these videos for you to deliver accurate medical expertise to the best of my ability (especially during this covid pandemic).
⏩ Timestamps, click to skip ahead!
00:00 - Introduction
00:44 - How COVID Kills Some People (Starting of the explanation)
17:00 - How do we get COVID Patients with ARDS Better?
17:55 - Why do some COVID Patients get ARDS, and Why do some Die?
20:55 - What do we know about COVID?
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We know this covid is mainly transmitted by respiratory droplets, and through contact, by getting into our mucosa, like our mouth, nose, and eyes. Although less common, it also can be transmitted through aerosol, meaning airborne. Most likely, when you have people in an enclosed space, such as an elevator, someone sneezes or coughs without covering their mouths, and someone else can inhale it in.
This covid attaches to cells in our body by this ACE2 receptor. This ACE2 receptor is only located on specific cells in our body. It's on our tongue, in our nose, back of the throat, and in our lungs. Specifically, it's only located on our type II alveolar cells within the lungs.
ARDS develops in about 4 to 5% of COVID patients. And of all the people who get covid, the mortality rate is around 1 to 2% or max 3%. So why do some COVID patients get ARDS, and why do some die? There are different reasons, and let's talk about them. It could be one of these reasons, but more likely, it's a combination of these reasons.
1. The covid only gains entry into our cells that express the ACE2 receptor. They are located on multiple sites. Besides being in the lung, they're in your mouth, nose, throat, stomach, small intestine, colon, skin, lymph nodes, thymus, bone marrow, spleen, liver, kidney, brain, and testes.
2. It makes sense that if the virus only gets into your mouth, nose, or throat, but not the lungs, it would cause only cold-like symptoms. But if the covid gets all the way down into the alveoli of your lungs, that's what's going to cause ARDS. And by the way, the ACE2 receptors in your gut probably explain why some patients get nausea, vomiting, and diarrhea.
3. The amount of virus you get into your body likely determines how sick you get. This is what we call the viral load.
4. The inflammatory reaction with COVID is extremely complicated, with many different proteins and hormones and interleukins at play. But there are several known genetic polymorphisms of these proteins that likely make some people more prone to getting worse illnesses than others. A genetic polymorphism simply means a variation on a particular gene. For example, there are genetic polymorphisms for the ACE gene and IL-6. So, basically, a lot of it just comes down to our genes.
5. Because the 5th reason has to do with estrogen. Estrogen is known to inhibit the effects of IL-6, which plays a massive role in this cytokine storm. This might explain why women have less severe disease overall than men.
6. The 6th reason is that people are already taking certain medications for those on an ACEI such as lisinopril or an ARB like losartan, telmisartan, or candesartan, or irbesartan. Or people who take hydroxychloroquine for lupus or rheumatoid disease. Or people who take tocilizumab, an IL-6 receptor inhibitor. Are these COVID patients less prone to getting severe illnesses? My guess is yes.
Doctor Mike Hansen, MD
Internal Medicine | Pulmonary Disease | Critical Care Medicine
Website: doctormikehansen.com/
Doctor Hansen's Courses: doctormikehansen.com/courses/
Contact and Social Media Links: doctormikehansen.com/contact/
#covid
All Comments (21)
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Doctor Mike Hansen's Programs ⏩ FULL Course for MORE ENERGY: learn.doctormikehansen.com/products/increase-energ… FREE Course for MORE ENERGY: doctormikehansen.com/6-days-to-more-energy/
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Great job Doc! Thank you for that awesome explanation. My husband and I were stricken with COVID19. My husband's lungs were in pretty bad shape, as you've explained. After 28 days in ICU, 23 days on the ventilator and the doctors having done all they could, God gave us a miracle! The medical staff calls him The Miracle Man. After 64 days, he's back home and in therapy 2x per week! We're so thankful to have overcome this wicked virus! Thank you Jesus! I pray for you and all those that are working so hard to save lives. You are appreciated! 🤗💜🙏🏾
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June 18th 2020 I woke up with running nose and got better next day, and next day lost smell and taste. Coffee taste and smell like sandy sour. Now 23rd June and getting better. Test came positive yesterday as I already know due to loss of smell and taste. I am 35 year old male and healthy, no smoking or drinking alcohol. Prayers for all and may God bless us all. Stay positive and healthy.
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I am 73 years young. Have been taking Zinc since 2012 because I worked in a hospital prison. That same year my apartment was in fasted with biting mites. The MD put me on Ivermection. As the pandemic emerged in 2019 I started taking Vit D, C , and Cranberry. . My immune system must be pretty good and I have not gotten Covid. I am blessed 🙌.
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My son in law is in ICU now with Covid. I can't get over how fast things happen. Please say a prayer for him!!
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I appreciate the shout outs to the cleaning crew because I notice they mention Nurses and Doctors a lot.
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As a nurse I have always had the highest of respect for those who can explain things to the lay person. Thanks for the post.
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My mother died of COVID-19 back in 2021 . RIP Mom you are missed😢😢😢
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my dad he is 97 he had covid and pull through that God today is his birthday.
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This takes me back to high school when I had no idea what my teachers were talking about but I had to keep listening and pretending I was getting everything. Hats off to all the doctors out there. That's a lot of information to know about.
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He explained everything about lung cells n functions so beautifully and even gave pictures and I still have no idea what he was talking about 😪
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I walked into the ER with my o2 at 72, had pneumonia with Covid (took 3 tests to get a + covid result), my lungs looked basically like the picture you had shown completely cloudy, they could not hear breath sounds at all. I had ARDS as well, went into the ICU and avoided the vent by doing everything my nurse told me to do. I proned up to 16 hrs a day, I used my spirometer as much as I could, I coughed up and spit out all the nasty that I could, I used the Aerobika as much as I could (not sure if that's the real name but it's the name on the side of the device) but I did everything to a T that they asked and more if my body let me. I was in the ICU for 4 days, then a regular room for 2 days and walked out of the hospital not having to take o2 at home. My nurses and doc were amazed and had no words as to why. I'm a 39 yr old obese stubborn SOB who never thought to give up and was determined to make it home for my middle child's bday (I did!). I was admitted on Thanksgiving of 2021, as of today (2/9/22) I have lasting brain issues from the ARDS, not anything catastrophic but memory issues, hard to find words I'm trying to say, get lost easily and my lungs still give me hell trying to exercise or walk a big store. I don't complain because I know I'm one of the very few like me to get out alive. I honestly had no idea just how lucky I am until watching this though.
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Dr. Mike, I just contracted C-19. Your videos are keeping me out of the hospital 🏥. We are very fortunate to benefit from your generosity. I will not even be able to interact with my internal medicine doctor. She’s incredibly overwhelmed. Thank you and know that you are saving the lives of people you will never meet in this lifetime. Well done 👍
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I swear some of these comments are so bizarre. I'm a physician as well and I appreciate all your hard work and dedication. Thank you for your service!
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Thank you for giving shouts out thanking the cleaning crew they are first responders also, need to be recognized.
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My brother had COVID pneumonia and recently passed away on Feb 19th. He just couldn’t beat this. He was only 56. I started watching your videos when he was in the hospital and found them very informative. It’s to late for my brother but I hope they find something to help save others. Thank you for trying to explain all of this to us.
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People died because they were sent home from the ERs & told, "Drink Lots of Fluids, Take Tylenol and get lots of Rest." 3-4 Days later, the Viral Infection had become Bacterial in the Alveoli and it was too late to save the Patient I already had a supply of BIAXIN & Quinine Syrup. As soon as I got sick, I took the Concentrated QUININE Syrup and took the Macrolide Antibiotic. My Fever and Chest Pressure were gone in 3 Days.
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The dry humour in these videos is getting better and better. It’s gold.
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"Wow, I look so young back then." Yeah dude. 2020's been real hard on all of us, man.
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My husband takes Ace inhibitor for HBP. He caught first wave of Covid19 and breezed thru it. I had it bad and barely missed going to ER. This virus strikes indiscriminately and no one can be sure how one's body will react. Thank you Dr Hansen for your informative videos.
