Vitamin D and dementia

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Published 2023-07-25
Vitamin D deficiency and insufficiency among US adults: prevalence, predictors and clinical implications

www.cambridge.org/core/journals/british-journal-of…

(University of Michigan School of Medicine, 2018)

Vitamin D deficiency (VDD) and insufficiency (VDI) are increasing at a global level

Serum 25-hydroxyvitamin D (25(OH)D) measurements were collected from 26,010 adults

(National Health and Nutrition Examination Survey, NHANES)

VDD, less than 50 nmol/l (20 ng ml)

VDI, 50 to 75 nmol/l (20 – 25 ng ml)

Prevalence

VDD, 28·9%

VDI, 41·4 %

Adults who were black, less educated, poor, obese, physically inactive and infrequent milk consumers

Obese adults, 3·09 times higher prevalence of VDD

(1·80 times higher prevalence of VDI)

Physically inactive adults, 2·00 times VDD

(1·36 times higher prevalence of VDI)

Vitamin D status in the United States, 2011–2014

academic.oup.com/ajcn/article/110/1/150/5487983?lo…

Persons with higher vitamin D dietary intake or who used supplements had lower prevalences of at risk of deficiency or inadequacy.

Vitamin D deficiency 2.0: an update on the current status worldwide

www.nature.com/articles/s41430-020-0558-y

Most studies did not meet the basic requirements of a nutrient intervention study

~40% of Europeans are vitamin D deficient,

and 13% are severely deficient

Vitamin D deficiency

(serum 25-hydroxyvitamin D less than 50 nmol/L or 20 ng/ml),

associated with unfavourable skeletal outcomes, including fractures and bone loss

Level of more than 50 nmol/L or 20 ng/ml is, therefore, the primary treatment goal

Severe vitamin D deficiency, below less than 30 nmol/L (or 12 ng/ml),

dramatically increases the risk of excess mortality, infections, and many other diseases,

and should be avoided whenever possible.

Given its rare side effects and its relatively wide safety margin, it may be an important, inexpensive, and safe adjuvant therapy for many diseases,

but future large and well-designed studies should evaluate this further.

Vitamin D supplementation and incident dementia: Effects of sex, APOE, and baseline cognitive status

alz-journals.onlinelibrary.wiley.com/doi/10.1002/d…

Vitamin D exposure was associated with 40% lower dementia incidence versus no exposure.

(Prospective, n = 12,388)

Low vitamin D serum levels as risk factor of Alzheimer’s disease: a systematic review and meta-analysis

ejnpn.springeropen.com/articles/10.1186/s41983-023…

Serum vitamin D levels, related to cognitive dysfunctions, e.g. dementia, including Alzheimer’s disease

Past studies vary in results on whether vitamin D levels correlated with the development of AD.

Meta-analysis, up to December 2022

AD, 75% of dementias

Results

6 studies, n = 10,884

Vitamin D receptors throughout the brain

Patients, vitamin D serum levels (less than 25 ng/ml),

had an increased risk of developing AD,

compared to more than 25 ng/ml

HR: 1.59

Severe deficiency (less than 10 ng/ml) having the strongest association,

compared to moderate vitamin D deficiency (10–20 ng/ml).

Vitamin D may promote the clearing of amyloid plaques

Vitamin D also prevents cognitive dysfunction via neuroprotection, neurotrophy, neurotransmission, and neuroplasticity

Potential to prevent neuroinflammation, inhibits proinflammatory cytokines

www.gov.uk/government/publications/vitamin-d-for-v…

In the UK during autumn and winter,

everyone is advised to take a supplement containing,

10 micrograms (400 international units) of vitamin D a day
ods.od.nih.gov/factsheets/VitaminD-HealthProfessio…

All Comments (21)
  • My mother, housebound and never in the sun, died of dementia. Her younger brother still running the family farm at 87 years old. Never been inside a day in his life. Never used sunscreen. Theres a massive correlation between the "sun fear" of the last fifty years, people terrified of the sun, using ridiculous amounts of sunscreen, and then the massive use of statin drugs just sucking the life giving cholesterol out of peoples brains, and that beautiful food pyramid of the last fifty years. The results are exacly as expected.
  • @lyndaholly
    My 88 yr old husband died in April after surviving a 13 year diagnosed progression of vascular dementia. I kept him at home and cared to all of his needs without assistance, as I wouldn't risk introducing Covid into our environment by any visiting h.c. workers. I believe that his longterm success over the progression of his brain degeneration was a combination of several factors, one of which was my commitment to giving him adequate COD Liver Oil capsules daily, along with exposure to fresh air and sunlight when possible. I am convinced that if he had been institutionalized, he would have perished much younger, because at home "he" was still "himself " , a dearly loved man with symptoms of a disease. The experience of caring for him taught me much about him, his disease, and about myself and my commitment to him. Even with all of the extreme challenges in the last three to four years, the dementia didn't succeed in killing him or in dominating his memories. It was a misdiagnosed gastric bleed that led to his death, and his last words were words of love when he repeatedly asked me, from his hospital bed. "are you OK? are you OK? are you OK?" Our love and my determination to keep him safe and well is the reason why he didn't sooner. His dementia pales in comparison to my own struggle with his loss. I am the one who is "lost".
  • In my 30s I began dealing with depression and body aches. My doctor tested my Vitamin D, and it was low. It was near 20 ng/ml. I started taking 5000 IU a day. It was remarkable how quickly my pain levels and mood improved. Even taking 5000IU (125 mcg) daily, my blood levels never go over 60 ng/ml. Vitamin D has been a life saver for me.
  • @patd.4773
    I was just diagnosed with mantle cell lymphoma. Oncologist hoped that my D3 would be at least 30 prior to chemo. Last test 4 years ago was 25. After watching your videos 3+ years ago I started taking D3 as well as spending more time outside. I just tested at 60! I can’t thank you enough for your advice!
  • @JesusIsKing96
    This is a warning for ALL people out there. When you go visit your doctor and they get bloods done and they say they are normal, no steps to be taken, ask for a print out. My mam was feeling very tired, low mood, various other symptoms. The doctor said her bloods came back fine. Well my dad asked for a print out and low and behold, yes my mam was in the normal bracket, but right at the bottom end of it. So if for example the normal was 50-80 range, then my mam was either 50 or 51. To me, if you are this low in the normal range and it can be as much as 80, then surely, if that person is presenting with these symptoms,the doctor should still be prescribing something to improve their condition! Doctors do not care these days about their patients, all they want is more pay and less hours. Even their bedside manners have diminished over the years. My mam is now thankfully on a couple of vitamins which has improved her health. Something as easily fixable as that!.
  • Not saying VitD isn't important. But my dad died of dementia (and cancer, but it was the dementia that did him in) and he was out in the Arizona desert sun most days and for at least an hour. I doubt he was deficient until the last season where he became housebound. I really think it was his anger that aided the disease. He ate well and mostly good food. He exercised regularly, he had a sense of humor, but he held onto a grudge like a bulldog. Anger releases chemicals in the body that are deadly.
  • @Jan-wd1is
    I'm a nurse and our Docs started prescribing Vit D3 to nearly all our patients in the rehab unit. This was at least 15 yrs ago, but it seems not many MDs are doing it generally.
  • @pattibennett8774
    Very interesting information, thank you. In May of this year I very suddenly thought I had had a stroke. Age 63, soon to be 64, obese. Had been plagued with crushing fatigue, rapid and uncontrollable weight gain, insatiable hunger, brain fog, balance issues, and more. Stood up, almost fell down, right sided weakness, just a hot mess. Anyway long story short, my Vit D was tested and came back at the astronomical level of 6 ng/mL. My HbA1c puts me in the diabetic category (close but still technically diabetic), and my serum cholesterol is high but surprisingly not too bad considering. Oddly enough my immune system was still functioning fine, I rarely ever get sick and my bone density seemed to have survived this intact. So I immediately began taking 5000 IU Vit D/day. So it's been just over 3 months and I need to schedule follow up blood work. I've lost over 30 pounds, my brain fog has lifted considerably, balance is better, I am being very cognizant of what and how much I'm eating but I'm no longer ravenously hungry all the time. I'm very interested in the results of my blood work coming up. If I had to quantify it, I'd say I'm feeling like I'm at about 80% improved. Still have a way to go but feeling so much better. I'm a nurse. I'm reasonably well educated. And I didn't know the impact that vitamin D has.
  • My doctor told me to get my vitamin D up at the beginning of Covid. He told me that I would be much more susceptible to hospitalization or worse if I didn't. Good doctor. I took his advice and have been supplementing ever since.
  • @americangal49
    USA here. My friends 92 year old healthy, independent mother living alone fell and broke her hip during Covid 19. Surgery went well, but her heart was broken because her daughter couldn’t visit her and the hospital would not allow her daughter to drop off her mothers supplements and vitamins. When she went to a rehab center, they wouldn’t allow it either. Her mother’s morale went down and phone calls weren’t the same. Her mother showed some signs of dementia and a died suddenly. ‘Natural causes. ???’ I think not. She was without her supplements for 12 weeks and without her family visiting her. So sad for a vibrant woman.
  • I was diagnosed with MS in 2005 and had it 2 years+ before. I decided, with scepticism, to try Vitamin D3 as some had mentioned. It was making MORE difference than my injection therapy!!! I also noticed my depression had lifted and I felt happier. In the end my neurologist ADMITTED that the vitamin D3 HAD made a difference in my case. If you have MS you MUST try vitamin D3. D3 works best with MS, it seems.
  • @promacpic
    Vitamin D deficiency seems to be highly correlated with most if not all autoimmune related degenerative diseases. Sadly, once you find out you’re deficient, a lot of irreversible damage may have already occurred. I found out I was deficient when I was around 47 (I’m now 58) - much too late IMO. It may have contributed to years frequent colds & infections, allergies, back pain, tinnitus, cataracts & God only knows what else I’ll find down the road. Vitamin D deficiency seems to be at the root of most if not all autoimmune related degenerative issues. Now I get tested every year.
  • @GaryRockliff
    My dad passed away 2 weeks ago, he had dementia and urostomy bag. He would urinary tract infections a few times....unfortunately in my dads case he's unable to feel the pain of the infection. Unfortunately the infection progressed rapidly into Sepsis and he passed away from septic shock. Sepsis is a major killer of the elderly with dementia because they ate unable to commincate what is wrong. When the angels took him it was a blessing, dementia is terrible terrible disease that affects family care givers immensely. 🙏🌼
  • @travelguy1564
    You said: "Higher levels of Vitamin D lower Dementia risk by 59 percent" WOW!!! That's absolutely stunning, Dr Campbell!!!
  • @dogsmumm
    When you mentioned the reduction in morbidity based on serum Vit D levels, my jaw dropped.
  • @susanbade9773
    We have to take care of ourselves and be responsible for our health............few docs give proper care anymore....thank you for being someone who truly cares about us and give us great information consistently!!
  • @TheGardenAddict
    I have serum D checked on all of my nutrition clients. In functional medicine and naturopathic medicine it's been known for a long time that serum levels below 50ng/mL are insufficient for optimum health. We shoot for 50 to 70 or 80 ng/mL. 5,000 IU daily usually does the trick. Obese clients sometimes need as much as 50,000 IU daily for a period of time to get levels high enough. As far as studies go: no money to be made means no studies done. With nutrition and supplements bad advice is given to keep us needing drugs. The pharmaceutical industry will go as far as doing studies to make supplements look dangerous. For example, they'll give rancid fish oil supplements to people and then say fish oil supplements cause prostate cancer. Or they'll give a particular synthetic form of vitamin E and say it causes death. Those studies make it in the mainstream media. In the US, there have been attempts to "regulate" supplements for our "safety." Big pharma either wants control or have them taken off the market. They even attempt having compounds classified as drugs so that a prescription is needed, which they did with NAC. Once it becomes common knowledge the value of vitamin D, my guess is they will work hard to have it classified as a drug. None of this should surprise anyone after what was done during Covid and the fraudulent studies done to "prove" that repurposed drugs aren't effective. Governments and DOD are often involved in studies to make nutrition and supplements look lame. Again, just look at what happened during Covid. It is psychopathic. Been going on long before Covid.
  • @gpalmerify
    Dr. Campbell's mention of Magnesium along with Vitamin D supplementation has been very helpful to my wife and I. We both wait to take our Magnesium Citrate powder before bedtime since it's calming effect allows us to drop off rather rapidly them wake up alert. A good night's sleep has been under emphasized IMO.
  • @George-Edwards
    Hello Dr Campbell, 10,000 IU a day for me because I'm missing about 25% of the last part of my small intestine. 2,000 for my wife and we're doing good. 60 ng/ml for me and 79 ng/ml for her so I think we are doing pretty good at keeping our Vit D levels up where they should be. We both had covid at the age of 72 and it was like a mild cold, no "Vax" no special drugs and it was over in 7 -10 days. George
  • @kimbowen5552
    Thank you SO MUCH for your reports. It's extremely hard for anyone to disagree with your reports because they are based on actual studies and facts. Don't let them shut you down.