Coronavirus Pandemic Update 37: The ACE-2 Receptor - The Doorway to COVID-19 (ACE Inhibitors & ARBs)

We're all going to be medical professionals after this pandemic

I can't be the only one who worries when there's been no update from this channel for days! Thanks for all that you do!

Finally a doctor's handwriting I can understand

Fascinating material, I hope many physicians treating covid19 patients are watching this channel. Thank you Dr. Seheult !

PLEASE KEEP MAKING THIS CONTENT!!! I'm an engineer, previously doctoral physicist, but I don't know squat about biology. I greatly appreciate the attempt to convey technical disciplinary jargon to us basketcases. Also appreciate the professionalism. Thank you!

I am a medical student and i am learning SO SO much from you. Thank you so much for your videos!

Clearly explained & even a non medically inclined person would understand a very complicated topic the way Dr. Roger Seheult expertly taught us. Your a God-given gift to the citizens of the world in times of outbreak & crisis like this. Not only that, every lucky listeners would be equipped w/ enough knowledge in the future to come. Thank you very very much!!!

Dr. Seheult, You should also be a teacher. I have no knowledge whatsoever in medicine or anything medical, but I understand everything you say. God bless you.

Thanks for the great and clear talk on this subject. As an MD and a virologist, the other thing I would point out is that viruses are usually "sneaky" in that they can use more than one receptor. There is flexibility in mechanisms for cell entry. Focusing on one entry pathway to prevent infection and virus replication has often been a way to reveal the alternative pathways. Nevertheless, I like the idea of using serine protease inhibitors. I hope you follow that story.

I've been doing my best to translate the information you are sharing with my father in law, mother-in-law, brother in law and sister in law over in Belarus, all doctors. They say "thank you!". Father in law is a pulmonary specialist. I was too squeamish to go into medicine. Just a lowly engineer that loves statistics. All the best to you sir!

Dr. Seheult, I'd like to have a beer with you when this is all over. These videos are very instructional, especially for a guy like me in the public safety field (law enforcement). I'm no doctor, just a dumb, lowly Detective in a medium sized agency, but we're all in this together, on the front lines. Thanks for the work you're doing here.

For those who think on logic these videos are extremely helpful, hopeful and are straight up game changers. Thanks so much for taking the time to do these especially with how busy you are. Stay safe out there too!

It's just a hypothesis. We don't know enough so we should keep taking our medication as normal.

A very welcome video to see today. I spent the entire day yesterday reading study after study trying to see all sides of the ACE questions. Husband and I are on Lisinopril for hypertension.

Thank you! I was listening only half-heartedly but then even I realized this was important. So I had to start over, but I am very grateful you give us credit for being able to follow the important consequences of our medicines upon these pathways. (Yes, even though we don't have definitive answers yet.)

I need to watch this several times for all the details. (Love your diagram, BTW.) Sounds like the "silver lining" of this situation will be research leading to new knowledge & treatments.

In Netherlands it's going ful-blown... Never in my whole life have I/we experienced such a thing. It's like I'm in a X-Files movie. So surreal. Been following almost all MedCrams since two months, so I'm familiar with China from the start, but when it finally hits home in your own town... The social distancing feels very scary and suffocating, make sure you exercise regularly to unstress your body-mind and see your dearest in a safe fashion. BE PREPARED, INFORM YOUR CIRCLE !!! IT WILL COME A SHOCK !!!

Good morning Dr. Seheult, here Rome, Italy. Thanks for your updates about coronavirus, even if I do not understand fully. I am not a doctor, I am an old style engineer used to look at numbers when they look strange. A piece of information that came out just this morning on the italian newspapers is about the extensive testiing they made in Vo' Euganeo, Veneto, one of the two villages, along with Codogno, Lombardy, where coronavirus was initially identified. The link among those two villages was identified in a farmer that traveled from one to the other and back. Being Vo' Euganeo a small village, 3000 people, they run several tests, even because it was just at the beginning. It came out that 50-75 % of the positive people had no symptoms at all. And that is rather strange when we also add the fact that, even when tests are run among people showing symptoms and/or strongly suspected to be a carrier, 80 % have no or very mild symptoms. That means that, if it was possible to run random testing, and that is more or less what they did in South Korea, people without symptoms would likely be around 70-80 %, 15-25 % would show only mild symptoms, with the reamaining requiring hospitalization at different levels. That would mean that the real fatality rate would be much lower than 1 %. That, from my point of view, is very strange when considering that the virus is "new". How is it possible that a "new" virus is active only on a small fraction of the population? That has no logic at all. SARS and MERS were extremely more dangerous. What could that mean? I suggest two possible explanations 1) SARS-nCov-2 was around since several years (penumonia cases increased significantly in italy in the latest years), but unnoticed until some variation allowed it to spread quickly instead that all around the influence season 2) Coronavirus is just a co-factor being activated in some specific circumstances, like presence of another virus or bactera, air pollution (Lombardy is the most polluted area all around Europe), use of some drugs as you suggest in this video. Maybe there are other explanations and I would like to read about those

Between your channel & UK Dr. John Campbell's channel, I've become so informed. My family & friends are all constantly messaging me & calling with questions. Compared to someone like a woman I work with...she heard a RUMOR that someone that works at a local store was confirmed for covid-19 (not true) & she happened to shop at that store a week ago. She left work with absolutely NO symptoms & drove like a madwoman to our local emergency room saying, "I have coronavirus, I have it!! I know I do!!" Then, when they turned her away because she had/has NO SYMPTOMS, she assumed she was already too far gone for the ER to even treat her & went home to self quarantine...for three days. As though three days would be enough if she were infected. The ER is, apparently, absolutely filled with people doing the exact same thing she did, no symptoms, etc... Please people, don't waste time & resources like she did. Please just think, pay attention to your body & follow the advice of doctors like the one speaking on this video. Thanks again.

Absolutely superb video overview. I look forward to sequel videos. Thank you for posting links to the relevant papers.